Applications of Bioinformatics in Cancer Detection

Applications of Bioinformatics in Cancer Detection

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Product Details

ISBN-13: 9781573315111
Publisher: New York Academy of Sciences
Publication date: 05/28/2004
Series: Annals of the New York Academy of Scienc , #1020
Pages: 277

Table of Contents

Prefaceix
Part I.Introduction
Proceedings: The Applications of Bioinformatics in Cancer Detection Workshop1
Overview of Commonly Used Bioinformatics Methods and Their Applications10
Part II.Genomics and Proteomics in Early Cancer Detection and Classification
New Developments in Cancer-Related Computational Statistics22
Bioinformatics Strategies for Translating Genome-Wide Expression Analyses into Clinically Useful Cancer Markers32
A Bayesian Hierarchical Model for the Analysis of Affymetrix Arrays41
Diagnostic Classification of Cancer Using DNA Microarrays and Artificial Intelligence49
Application of Bioinformatics in Cancer Epigenetics67
Pathway Databases77
Microarrays and the Gene Expression Profile of a Single Cell92
Bioinformatics Tools for Single Nucleotide Polymorphism Discovery and Analysis101
Numerical Deconvolution of cDNA Microarray Signal: Simulation Study110
Automated Interpretation of Protein Subcellular Location Patterns: Implications for Early Cancer Detection and Assessment124
Data-Driven Computer Simulation of Human Cancer Cell132
Application of the Random Forest Classification Algorithm to a SELDI-TOF Proteomics Study in the Setting of a Cancer Prevention Trial154
Improved Small Volume Lung Cancer Detection with Computer-Aided Detection: Database Characteristics and Imaging of Response to Breast Cancer Risk Reduction Strategies175
Evolutionary Fuzzy Modeling Human Diagnostic Decisions190
Bayesian Decomposition: Analyzing Microarray Data within a Biological Context212
Part III.Bioinformatics in Drug Discovery
InfoEvolve: Moving from Data to Knowledge Using Information Theory and Genetic Algorithms227
Applications of Machine Learning and High-Dimensional Visualization in Cancer Detection, Diagnosis, and Management239
Part IV.Glossary
Applications of Bioinformatics in Cancer Detection: A Lexicon of Bioinformatics Terms263
Index of Contributors277

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