Applying Genomic and Proteomic Microarray Technology in Drug Discovery

Applying Genomic and Proteomic Microarray Technology in Drug Discovery

by Robert S. Matson

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Product Details

ISBN-13: 9780203491133
Publisher: CRC Press
Publication date: 12/28/2004
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 256
File size: 7 MB

Table of Contents

QUANTITATIVE BIOLOGY: THE "OMICS" ERA
Introduction
Microarray Format
General Utility
The Omic Era
Role of Gene Expression Microarrays in Drug Discovery
Proteomics Today: The Great Challenge
Potential Role for Protein Microarrays in Drug Discovery
Critical Issues with Protein Microarrays
Future medicine: Pharmacoproteomics or pharmacogenomics?
References

COMMERCIAL MICROARRAYS
Introduction
In situ arrays
Ex situ or spotted arrays
3D and 4D chips
Flow-Thru biochips note: flow-thru is a general term when applied here, remove TM. This should have also been corrected in the book proofs.
Electronic biochips
Future opportunities
References

SUPPORTS AND SURFACE CHEMISTRIES
Introduction
Substrates
Summary
References

ARRAYING PROCESSES
Introduction
Creating spotted microarrays
Printing parameters
Protocols for printing nucleic acids
Protocols for printing proteins
References

GENE EXPRESSION: MICROARRAY-BASED APPLICATIONS
Introduction
Applications demonstrating DNA microarray utility
Biomedical research applications
References

PROTEIN MICROARRAY APPLICATIONS
Introduction
Spot theory
Applications demonstrating protein microarray utility
Measuring microarray performance
Other microarray formats useful for proteomic applications
References
Index

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