Arachidonate Remodeling and Inflammation

Arachidonate Remodeling and Inflammation

Paperback(Softcover reprint of the original 1st ed. 2004)

View All Available Formats & Editions
Choose Expedited Shipping at checkout for guaranteed delivery by Thursday, January 30
1 New & Used Starting at $134.31


Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer’s disease.
AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators.

Product Details

ISBN-13: 9783034895941
Publisher: Birkh�user Basel
Publication date: 10/21/2012
Series: Progress in Inflammation Research
Edition description: Softcover reprint of the original 1st ed. 2004
Pages: 243
Product dimensions: 6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

An outline of arachidonate remodeling and its biological significance.- Phospholipase A2 and remodeling in inflammatory cells.- Enzymatic and receptor mediated effects of secretory phospholipase A2 on the pathophysiology of inflammatory diseases.- Control of arachidonic acid levels in resting and activated U937 phagocytic cells by Ca2+-independent phospholipase A2.- Arachidonate remodeling and PAF synthesis in human neutrophils.- Control of long chain polyunsaturated fatty acid levels and the role of inhibitors of incorporation and remodeling on the biosynthesis of lipid mediators.- Remodeling of arachidonic acid in inflammatory cells of the human lung.- Arachidonate remodeling, platelet-activating factor signaling, and the inflammatory response in the central nervous system.- Remodeling of arachidonate and other polyunsaturated fatty acids in Alzheimer’s disease.- Lipoxins and resolvins: local mediators in endogenous anti-inflammation and resolution.- Metabolism and physiological significance of anandamide and 2-arachidonoylglycerol, endogenous cannabinoid receptor ligands.

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews