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Overview

Autoantibodies by

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self constituents of the body. This exciting new reference is an exhaustive review of the main autoantibodies identified up to now, with particular emphasis on those autoantibodies that display a clinical value. Each chapter is focussed on a single family of autoantibodies by reviewing their historical notes, definition, origin and source(s) of the antigen(s) recognized, genetic associations, pathogenic mechanisms that are mediated, method(s) of detection and clinical utility (disease prevalence/association, diagnostic value, sensitivity and specificity, prognostic value). An ideal reference for anyone involved in the field of autoimmune diseases.

* Incudes and exhaustive list of autoantibodies not covered by other publications
* Short reviews can easyily be checked for quick reference information
* Both basic and clinical aspects are covered

Product Details

ISBN-13: 9780080467238
Publisher: Elsevier Science
Publication date: 10/13/2011
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 872
File size: 16 MB
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About the Author

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University.

His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands.

He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity.

Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel - Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honored as Doctoris Honoris Causa, from Debrecen University (Hungary), and from 2009 he is honorary member of the Slovenian National Academy of Sciences. He has recently been awarded a Life Contribution Prize in Internal Medicine in Israel, 2012 as well as the ACR Master Award in 2013.

Prof. Shoenfeld has educated a long list of students (<25) being heads of departments and institutes.

Table of Contents

PREFACE
FOREWORD
¡V Autoantibodies: History and Horizons
INTRODUCTION: AUTOANTIBODIES-UNIQUE CHARACTERISTICS
What is an autoantibody?
Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity
Molecular Mimicry
Affinity and Avidity of Autoantibodies
Pathogenic Mechanisms and Clinical Relevance of Autoantibodies
Native Autoantigens Versus Recombinant Autoantigens
Redox-Reactive Autoantibodies
Predictive Autoantibodies
Autoantibody Subclasses
Idiotypes and Anti-idiotypes
Novel Diagnostic Methods for Autoantibody Detection
ALLERGIC DISEASE AUTOANTIBODIES
Human IgE Specific Autoantibodies and Autoantibodies to IgE Receptors
ANTINEUTROPHIL ANTIBODIES
Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase
Novel Thoughts on Antineutrophil Cytoplasmic Autoantibodies
Neutrophil-Specific Antinuclear and Anti-Cytoplasmic Antibodies in Chronic Inflammatory Diseases
Antineutrophil Cytoplasmatic Autoantibodies with Specificity to Proteinase 3
ANTINUCLEAR ANTIBODIES
Antinuclear Antibodies: General Introduction
Anti-nucleolar Antibodies
Anti-Chromatin (Nucleosome) Autoantibodies
Centromere Autoantibodies
dsDNA Autoantibodies
Histone Autoantibodies
Ku and Ki Autoantibodies
Neuronal Nuclear Autoantibodies, Type 1 (Hu)
Nuclear Envelope Protein Autoantibodies/Anti-laminin Autoantibodies
Anti-nucleosome Autoantibodies
Proliferating Cell Nuclear Antigen Autoantibodies
Anti-RA-33 Antibodies (Antibodies to the Heterogeneous Nuclear Ribonucleoprotein A2
Anti-Ribosomal P Antibodies
SS-A (Ro) Autoantibodies
Topoisomerase-I (Sci-70) Autoantibodies
SS-B (La) Autoantibodies
Anti-RNA Polymerase III Antibodies
AUTOANTIBODIES TO BIOLOGIC FACTORS/STRUCTURES
GW Bodies, P Bodies and Components of the miRNA Pathway
Golgi Complex and Endosome Antibodies
p53 Autoantibodies
Human Antiganglioside Autoantibodies
Human Anti-Ą-Galactosyl Antibodies
Autoantibodies in Therapeutic Preparation of Human Intravenous Immunoglobulin (IVIG)
Cytokine Antibodies
Cytoskeletal Autoantibodies/Anti-actin Antibodies
Fibrillarin Autoantibodies
Fibronectin Autoantibodies
Interferon-inducible Protein IFI 16 Autoantibodies
CARDIAC AUTOANTIBODIES
Autoantibodies in Atherosclerosis
Heat Shock Protein Autoantibodies
Myocardial Auto-antibodies and Their Clinical Significance
ENDOCRINE AUTOANTIBODIES
Glutamic Acid Decarboxylase Autoantibodies
Insulin Autoantibodies/Islet Cell Autoantibodies/Other Autoantibodies in IDDM
Antibodies to Adrenal, Gonadal Tissues and Steroidogenic Enzymes
Thyroglobulin Autoantibodies/Thyroid Peroxidase Autoantibodies/Thyrotropin Receptor
GI AND LIVER AUTOANTIBODIES
Anti-Intestinal Goblet Cell Antibodies
Tumor Associated Autoantibodies
Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection
Anti-tissue Transglutaminase and Anti-endomyisial Antibodies
Anti-gliadin Antibodies
Reticulin Autoantibodies
Liver Cytosol Antigen Type 1 Autoantibodies (LC-1), Liver Kidney Microsomal Autoantibodies (LKM), and Liver Microsomal Autoantibodies (LM)
Antimitochondrial Antibodies
Parietal Cell and Intrinsic Factor Autoantibodies
Smooth Muscle Autoantibodies
HEMATOLOGIC AUTOANTIBODIES
Coagulation Factor Autoantibodies
Autoantibodies in Heparin-Induced Thrombocytopenia
Platelet Autoantibodies
Red Cell Autoantibodies
Lymphocytotoxic Autoantibodies
KIDNEY AUTOANTIBODIES
Anti-ATP Synthase ƒÒ-Chain Autoantibodies
Glomerular Basement Membrane Autoantibodies
Nephritic Factor Autoantibodies
NEUROLOGICAL SYSTEM AUTOANTIBODIES
Acetylcholine Receptor and Muscle Specific Kinase Autoantibodies
Myositis Autoantibodies: Aminoacyl-tRNA Synthetase, Signal Recognition Particle, Mi-2, and PM-Scl Autoantibodies
Anti-MOG Antibodies
Antibodies to Hsp 70 in Inner Ear Disease
Autoantibodies in the Lambert-Eaton Myasthenic Syndrome (LEMS) and Amyotrophic Lateral Sclerosis (ALS)
Ganglioside Autoantibodies
Myelin Associated Antibodies: Myelin-associated Glycoprotein Autoantibodies,
Myelin Basic Protein Autoantibodies and Myelin Proteolipid Autoantibodies in Neurologic Diseases
Paraneoplastic Neurological Antibodies: 1. Nuclear
Paraneoplastic Neurological Antibodies: 2. Purkinje Cell Cytoplasm
Paraneoplastic Neurological Antibodies: 3. Additional Reactivities
Retinal Autoantibodies
Autoantibodies in Epilepsy
RHEUMATIC DISEASE AUTOANTIBODIES
Anti-fodrin Antibodies
Antibodies to Laminin
Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjogren¡¦s Syndrome
B2 ¡VGlycoprotein I Autoantibodies
C1 Inhibitor Autoantibodies
Autoantibodies to C1q
Anti-Collagen Antibodies
Anti-cyclic citrullinated peptide Antibody
Anti-endothelial Cell Autoantibodies
Lupus Anticoagulant Testing
Anti-cardiolipin Antibodies
Phospholipid Autoantibodies (Non Anti-cardiolipin)-Anti-Prothrombin Antibodies
Rheumatoid Factors
SKIN DISEASE AUTOANTIBODIES
Autoantibodies to Mucocutaneous Antigens
UNIQUE CLINICAL SITUATIONS
Autoimmunity and the Newer Biopharmaceuticals
Autoantibodies Against Tumor Suppressor Proteins
Detection of Autoantibodies Using Protein Arrays
Autoantibodies and Pregnancy Loss
Anti Glycan Antibodies
FUTURE DIRECTIONS

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