Autoimmune Endocrine Disorders, An Issue of Endocrinology and Metabolism Clinics of North America

Autoimmune Endocrine Disorders, An Issue of Endocrinology and Metabolism Clinics of North America

by Simon H.S. Pearce
Pub. Date:
Elsevier Health Sciences

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Autoimmune Endocrine Disorders, An Issue of Endocrinology and Metabolism Clinics of North America

Autoimmune disorders are amongst the most frequently encountered conditions in endocrine practice. The evidence-based approach to therapeutics and detailed evaluation of the outcome of existing treatment regimens have led to some advances in care delivery. Pragmatic reviews by leading international experts outline the clinical state of the art in several chapters of this issue of the Endocrinology and Metabolism Clinics of North America devoted to autoimmune disorders. Topics covered include the following: regulatory T cells as key players in tolerance and autoimmunity; immunology lessons from monogenic conditions such as AIRE; immunogenetics of T1D and AITD; advances in T1D therapeutics, including islet cell replacement and salvage; updates on TSHR structure, function, and monoclonal human TSHR antibodies; animal models of Grave’s disease; evidence-based and emerging modalities of treatment of Graves’ hyperthyroidism; patient selection and treatment of thyroid-associated ophthalmopathy; antibodies to steroidogenic tissues: Addison’s and POF; diagnosis and management of polyendocrinopathy syndromes; autoimmune parathyroid disease; and autoimmune hypophysitis.

Product Details

ISBN-13: 9781437704716
Publisher: Elsevier Health Sciences
Publication date: 05/08/2009
Series: Clinics: Internal Medicine Series
Pages: 240
Product dimensions: 6.00(w) x 9.10(h) x 0.60(d)

Table of Contents

Foreword Derek LeRoith xiii

Preface Simon H.S. Pearce xvii

Regulatory T Cells: Key Players in Tolerance and Autoimmunity Talal A. Chatila 265

Clearing the AIRE: On the Pathophysiological Basis of the Autoimmune Polyendocrinopathy Syndrome Type-1 Noriko Shikama Gretel Nusspaumer Georg A. Holläet;nder 273

Genetics of Type 1 Diabetes and Autoimmune Thyroid Disease Simon H.S. Pearce Tony R. Merriman 289

Advances in Type 1 Diabetes Therapeutics: Immunomodulation and β-Cell Salvage Frank Waldron-Lynch Kevan C. Herold 303

The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Multimerization, Cleavage, and Signaling Rauf Latif Syed A. Morshed Mone Zaidi Terry F. Davies 319

Toward Better Models of Hyperthyroid Graves' Disease Sel&ccidle;uk Dağdelen Yi-chi M. Kong J. Paul Banga 343

Treatment of Graves' Hyperthyroidism: Evidence-Based and Emerging Modalities Laszlo Hegedüet;s 355

Thyroid-Associated Orbitopathy: Who and How to Treat Jane Dickinson Petros Perros 373

Immunology of Addison's Disease and Premature Ovarian Failure Eystein S. Husebye Kristian L&ophi;vås 389

Fine Tuning for Quality of Life: 21st Century Approach to Treatment of Addison's Disease Nicole Reisch Wiebke Arlt 407

Diagnosis and Management of Polyendocrinopathy Syndromes Catherine J. Owen Tim D. Cheetham 419

Anti-Parathyroid and Anti-Calcium Sensing Receptor Antibodies in Autoimmune Hypoparathyroidism Edward M. Brown 437

Index 447

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