Autoimmunity: Methods and Protocols

Autoimmunity: Methods and Protocols

by Andras Perl (Editor)

Hardcover(2nd ed. 2012)

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Product Details

ISBN-13: 9781607617198
Publisher: Springer-Verlag New York, LLC
Publication date: 08/30/2012
Series: Methods in Molecular Biology , #900
Edition description: 2nd ed. 2012
Pages: 504
Product dimensions: 7.01(w) x 10.00(h) x 0.05(d)

Table of Contents

Prefacevii
Contributorsxi
1Pathogenesis and Spectrum of Autoimmunity1
Part I.Models of Pathogenesis in Human Autoimmune Disorders
2Mapping the Systemic Lupus Erythematosus Susceptibility Genes11
3T-Cell Signaling Abnormalities in Human Systemic Lupus Erythematosus31
4TCR [xi]-Chain Abnormalities in Human Systemic Lupus Erythematosus49
5Protein Kinase A and Signal Transduction in T Lymphocytes: Biochemical and Molecular Methods73
6Apoptosis and Mitochondrial Dysfunction in Lymphocytes of Patients With Systemic Lupus Erythematosus87
7Methods for Inducing Apoptosis115
8Measurement of Cytokines in Autoimmune Disease129
9Evaluation of Autoimmunity to Transaldolase in Multiple Sclerosis155
Part II.Animal Models of Autoimmunity
10Animal Models for Autoimmune Myocarditis and Autoimmune Thyroiditis175
11Animal Models of Insulin-Dependent Diabetes195
12Generation, Maintenance, and Adoptive Transfer of Diabetogenic T-Cell Lines/Clones From the Nonobese Diabetic Mouse213
13Experimental Use of Murine Lupus Models227
14The Anti-DNA Knock-In Model of Systemic Autoimmunity Induced by the Chronic Graft-vs-Host Reaction273
15Murine Models of Lupus Induced by Hypomethylated T Cells285
16The Mouse Model of Collagen-Induced Arthritis295
17Proteoglycan Aggrecan-Induced Arthritis: A Murine Autoimmune Model of Rheumatoid Arthritis313
18Mouse Models of Multiple Sclerosis: Experimental Autoimmune Encephalomyelitis and Theiler's Virus-Induced Demyelinating Disease339
19Experimental Autoimmune Encephalomyelitis363
20Animal Models of Scleroderma377
21Rodent Models of Experimental Autoimmune Uveitis395
22Autoimmune Depigmentation Following Sensitization to Melanoma Antigens421
Index429

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