Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 1 - Molecular Mechanisms

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 1 - Molecular Mechanisms

by M. A. Hayat

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Overview

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.

Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood.

Volumes in the Series

Product Details

ISBN-13: 9780124055353
Publisher: Elsevier Science
Publication date: 07/29/2013
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 360
File size: 4 MB

About the Author

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Table of Contents

I. GENERAL DISEASES 1. INTRODUCTION 2. MECHANISMS OF REGULATION OF P62 IN AUTOPHAGY AND IMPLICATIONS FOR HEALTH AND DISEASES  3. MOLECULAR MECHANISMS UNDERLYING THE ROLE OF AUTOPHAGY IN NEURODEGENERATIVE DISEASES 4. ROLES OF MULTIPLE TYPES OF AUTOPHAGY IN NEURODEGENERATIVE DISEASES 5. AUTOPHAGY AND CROHN’S DISEASE: TOWARDS NEW THERAPEUTIC CONNECTIONS 6. THE ROLE OF AUTOPHAGY IN ATHEROSCLEROSIS 7. TREATMENT OF DIABETIC CARDIOMYOPATHY THROUGH UPREGULATING AUTOPHAGY BY STIMULATING AMP-ACTIVATED PROTEIN KINASE 8. HYPERGLYCEMIA-ASSOCIATED STRESS INDUCES AUTOPHAGY: INVOLVEMENT OF THE ROS-ERK/JNK-P53 PATHWAY 9. ROLE OF AUTOPHAGY IN THE CELLULAR DEFENSE AGAINST INFLAMMATION 10. MYTOPHAGY PLAYS A PROTECTIVE ROLE IN FIBROBLASTS FROM PATIENTS WITH COENZYME Q10 DEFICIENCY 11. PRESENCE OF DIOXIN KIDNEY CELLS INDUCES CELL DEATH WITH AUTOPHAGY II. CANCER 12. MOLECULAR MECHANISMS UNDERLYING THE ACTIVATION OF AUTOPHAGY PATHWAYS BY REACTIVE OXYGEN SPECIES AND THEIR RELEVANCE IN CANCER PROGRESSION AND THERAPY 13. INDUCTION OF AUTOPHAGIC CELL DEATH BY ANTICANCER AGENTS 14. IMMUNOGENICITY OF DYING CANCER CELLS - THE INFLAMMASOME CONNECTION. AUTOPHAGIC DEATH ARRIVES TO THE SCENE 15. SELENITE-MEDIATED CELLULAR STRESS, APOPTOSIS AND AUTOPHAGY IN COLON CANCER CELLS 16. ENHANCEMENT OF CELL DEATH IN HIGH GRADE GLIOMA CELLS: ROLE OF N-(4-HYDROXYPHENYL) RETINAMIDE-INDUCED AUTOPHAGY 17. CISPLATIN EXPOSURE OF SQUAMOUS CELL CARCINOMA CELLS LEADS TO THE MODULATION OF AUTOPHAGIC PATHWAY III. TUMORS 18. AUTOPHAGY, STEM CELLS AND TUMOR DORMANCY 19. DEATH- ASSOCIATED  PROTEIN  KINASE 1 SUPPRESSES TUMOR GROWTH AND METASTASIS VIA AUTOPHAGY AND APOPTOSIS 20. TRIM13, NOVEL TUMOR SUPPRESSOR: REGULATOR OF AUTOPHAGY AND CELL DEATH 21.HYPOXIA-INDUCED AUTOPHAGY PROMOTES TUMOR CELL SURVIVAL

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