The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success.
The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies.
The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology.
- With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far
- Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors
- Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research
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About the Author
Bernd Kaspers graduated as a veterinarian in 1986 at the University of Munich and completed his doctoral thesis (Doctor of Veterinary Medicine) in 1989. He subsequently worked as a post-doc at the United States Department of Agriculture, Agricultural Research Service, Livestock and Poultry Sciences Institute, Beltsville, MD, USA and returned to the University of Munich in 1992 where he became a full Professor for Animal Physiology in 1997.
Since his dissertation he has focused on avian immuno-physiology investigating B-lymphocyte biology, cytokines and the mucosal immune system in chickens. This work included studies on a range of infection models such as avian coccidiosis, avian influenza, Marek’s Disease and Salmonella infections. His research is documented in more than 85 publications in peer-reviewed journals, several reviews and book chapters.
His work is funded by grants from the German Research Foundation, the Federal Ministry of Education and Research, the European Union and through several co-operations with the poultry and vaccine industry.
Bernd Kaspers is member of the German Society for Immunology and as such has been speaker of the Veterinary Immunology Study Group of the society for the last 6 years. In 2004 he hosted together with Thomas Goebel the 8th Avian Immunology Research Group Meeting in Munich with more than 120 participants.
Professor Pete Kaiser is Head of the Division of Infection and Immunity and Chair in Animal Infectious Diseases at The Roslin Institute&R(D)SVS, University of Edinburgh. He is also Head of the newly established National Avian Research Facility at Roslin.
He has published over 130 primary research papers and holds 3 patents, primarily in avian immunology and genetics, and is currently supported by grants from the BBSRC, EU, industry and charities. He has won competitive funding totalling over £5M since joining The Roslin Institute in 2010. He holds visiting appointments at the Universities of Queensland and Liverpool and is on the Editorial Boards of 6 journals. He is a trustee of the Houghton Trust and serves on several BBSRC working and advisory groups. In 2009 he was awarded the Houghton Lecture at the World Veterinary Poultry Association meeting in Morocco. Industrial collaborators include Zoetis Animal Health, CEVA Sante Animale, HyLine, Cobb-Vantress and Aviagen.
Table of Contents
1. The importance of the avian immune system and its unique features 2. Structure of the avian lymphoid system 3. Early ontogeny of the avian immune system 4. B cells, bursa, development of antibody repertoire 5. T cell development and function 6. Antibodies 7. Innate immune responses 8. MHC and its role in avian immune responses 9. Antigen Presenting Cells 10. Cytokines and chemokines 11. Immunogenetics and mapping immunological functions 12. The mucosal immune system 13. Enteric immune system 14. Respiratory Immune system 15. Reproductive immune system 16. Immunodepressive diseases&immune evasion 17. Factors modulating the immune system 18. Autoimmune diseases of poultry 19. Tumours of the immune system 20. Practical aspects of vaccination 21. Comparative immunology of domesticated agricultural species 22. Ecological Immunology
App. A. Chicken strains useful for defining the genetics of immune traits App. B. Resources available for studying avian immunology