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Caister Academic Press
Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis

Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis

by Karl Wooldridge


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Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis

Secreted proteins are particularly important in bacterial pathogenesis. These proteins have a range of biological functions from host cell toxicity to more subtle alterations of the host cell for the benefit of the invader. The importance of protein secretion to bacterial pathogens is exemplified by the array of mechanisms that have evolved for this purpose. This extensive publication - on bacterial secreted proteins, the secretory systems of bacteria, and the vital role of secreted proteins in bacterial pathogenesis - will be of immense value to all microbiologists, molecular biologists, public health scientists, and researchers engaged in the study of pathogenesis, drug design, and vaccine development. A skillful selection of topics and a panel of acknowledged experts have ensured that this volume will become an important reference source for many years to come. The book is divided into two sections. The first section describes the various protein secretion systems, including mechanisms for secretion across the cytoplasmic membrane of Gram-negative and Gram-positive bacteria, the specialized mechanisms for secretion across the Gram-negative outer membrane, the systems for transport across both membranes of Gram-negative bacteria, the protein secretion systems in Gram-positive bacteria, the secretion of surface fimbrae/pili, and the less well-defined pathways. Section two describes the protein secretion mechanisms and secreted proteins of a number of important human, veterinary, and plant pathogens and their role in the pathogenicity of these organisms. The pathogens covered have been selected on the basis that there is active research on protein secretion by these pathogens and they employ a diverse array of secreted proteins and protein secretion systems. Each of the book's chapters can be read in isolation. The book constitutes a broad and in-depth description of the current knowledge of bacterial protein secretion and its role in pathogenesis. It is a recommended reference volume for all microbiology libraries.

Product Details

ISBN-13: 9781904455424
Publisher: Caister Academic Press
Publication date: 03/02/2009
Pages: 512
Product dimensions: 7.00(w) x 10.00(h) x 1.20(d)

Table of Contents

List of contributors v

Preface xi

Part 1

1 The Sec Protein Secretion System Koreaki Ito Hiroyuki Mori 3

2 The Twin-arginine Translocation Pathway Sascha Panahandeh Eva Holzapfel Matthias Muller 23

3 Type I Bacterial Secretion Systems Stefan Jenewein I. Barry Holland Lutz Schmitt 45

4 Type II Secretory System (T2SS) in Gram-negative Bacteria: a Molecular Nanomachine for Secretion of Sec and Tat-dependent Extracellular Proteins Gerard P.F. Michel Rome Voulhoux 67

5 The Type III Secretion System Isabel Sorg Guy R. Cornelis 93

6 Mechanistic and Structural Analysis of Type IV Secretion Systems Christian Baron 117

7 Type V Secretion Anthony Scott-Tucker Ian R. Henderson 139

8 Assembly and Secretion of Surface Fibres in Gram-Negative Bacteria David G. Thanassi Matthew R. Chapman Subhra Chakraborty 159

9 Secretome Mapping in Gram-positive Pathogens Mark J.J.B. Sibbald Jan Maarten van Dijl 193

10 Non-classical Secretion Jannick D. Bendtsen Karl G. Wooldridge 225

Part 2

11 Secreted Proteins and Virulence in Salmonella enterica Michael Hensel 239

12 Secreted and Exported Proteins Important to Mycobacterium tuberculosis Pathogenesis Jessica R. McCann Sherry Kurtz Miriam Braunstein 265

13 Protein Secretion and the Pathogenesis of Campylobacter jejuni Neil J. Oldfield Karl G. Wooldridge 299

14 Listeria monocytogenes Mickael Desvaux Michel Hebraud 313

15 Protein Secretion and Pathogenesis in Neisseria meningitidis David P Turner Karl G Wooldridge Dlawer Ala'Aldeen 347

16 The Role of Secreted Proteins in the Pathogenesis of Helicobacter pylori Infection Robin M. Delahay Darren P. Letley 361

17 Protein Secretion in Legionella pneumophila Emmy De Buck ElkeLammertyn Jozef Anne 401

18 Bordetella pertussis Zoe E. V. Worthington Nicholas H. Carbonetti 413

19 Secreted Proteins of Vibrio cholerae Bethany Kay Boardman Karla J. Fullner Satchell 433

20 The Secreted Proteins of Pseudomonas aeruginosa: Their Export Machineries and How They Contribute to Pathogenesis Kim R. Hardie Stephanie Pommier Susanne Wilhelm 451

21 Secretion systems of the enterobacterial phytopathogen, Erwinia Terry J. Evans Daniel Perez-Mendoza Rita E. Monson Hannah G. Stickland George P.C. Salmond 479

Index 505

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