The following papers were presented at an international workshop on benzo diazepine receptor ligands, memory and information processing, held during the 15th CINP meeting in Puerto Rico in December 1986 and organised by the editors and T. Roth. This workshop was aimed at reviewing and reflecting on past experience with benzodiazepines, evaluating the current state of knowledge of the actions of psychotropic orugs (particularly benzodiazepines, fJ-carbolines and benzodiazepine antagonists), and laying a basis of interest and speculation for future research into the potential use of these drugs in disorders of memory and information processing. There is much published material regarding the theoretical underpinnings of what psychologists call "memory", and doubtless there will be several more libraries filled with theses on the topic before a consensus is reached as regards basic definitions or even meaningful distinctions between for example, "short" and "long"-term memory - everyone has his own particular theory. The qualitative and quantitative diversity of the different approaches might seem to present an insurmountable problem for the psychologist seeking a unified conceptual framework. In practice the various theories produce a plethora of pragmatic and experimental techniques for psychopharmacologists and clinicians to use when investigating drugs with putative amnestic or promnestic properties.
Table of ContentsTheoretical Aspects of Memory and Information Processing.- Models of Memory: Information Processing.- Measuring Memory.- Drugs and Information Processing in Skilled Performance.- Measures of Memory and Information Processing in Elderly Volunteers.- Psychometric Assessment of Drug Effects.- Assessment of the Effects of Drugs on Memory.- Information Processing, Critical Flicker Fusion Threshold and Benzodiazepines: Results and Speculations.- Individual Differences in Benzodiazepine-Induced Changes of Memory.- Clinical and Psychological Aspects of Memory Dysfunction.- Clinical Relevance of Effects of Benzodiazepines on Learning and Memory.- The Effect of Anxiolytic Drugs on Memory in Anxious Subjects.- Sleep and Memory.- Benzodiazepine-Induced Amnesia and Anaesthetic Practice: A Review.- Benzodiazepines, Memory and Information Processing.- Lormetazepam, Memory and Information Processing: A Review.- Anterograde and Retrograde Amnesia after Lormetazepam and Flunitrazepam.- Reversal by Caffeine of Triazolam-Induced Impairment of Waking Function.- ?-Carbolines and Benzodiazepine Antagonist Actions on Memory and Vigilance.- Bidirectional Nature of Benzodiazepine Receptor Ligands Extends to Effects on Vigilance.- Animal Model Studies of Benzodiazepine-Induced Amnesia.- ?-Carbolines as Tools in Memory Research. Animal Data and Speculations.- ?-Carbolines as Tools in Memory Research: Human Data with the ?-Carboline ZK 93426.- Benzodiazepine Receptor Ligands: Tools for Memory Research in Clinical Pharmacology.- Résumé.- Benzodiazepine Receptor Ligands, Memory and Information Processing: Issues, Comments and Prospects.- Author Index.