Bioartificial Organs II: Technology, Medicine and Materials

Bioartificial Organs II: Technology, Medicine and Materials

Hardcover(Library Binding)

$140.00

Product Details

ISBN-13: 9781573311946
Publisher: New York Academy of Sciences
Publication date: 06/28/1999
Series: Annals of the New York Academy of Scienc
Pages: 415
Product dimensions: 6.50(w) x 1.50(h) x 9.50(d)

Table of Contents

Dedicationix
Acknowledgmentsxi
Introductionxiii
Part I.Overview
Bioartificial Organs: Risks and Requirements1
Part II.Novel Materials
Control of Complement Activities for Immunoisolation7
Designing Biomaterials to Direct Biological Responses24
New Microcapsules Based on Oligoelectrolyte Complexation36
Development of Cellulose Sulfate-based Polyelectrolyte Complex Microcapsules for Medical Applications46
Radiation Sterilization of a Bifunctional Cement Formulation of Hydroxilapatite-Plaster-Polymers64
Part III.Encapsulation: Fundamentals and Applications
Artificial Cells, Encapsulation and Immobilization71
Physico-Chemical and Mass Transfer Considerations in Microencapsulation84
In Situ Electrochemical Oxygen Generation with an Immunoisolation Device105
Conformal Coating of Small Particles and Cell Aggregates at a Liquid-Liquid Interface126
New Multicomponent Capsules for Immunoisolation135
Encapsulation for Somatic Gene Therapy146
Review--The Use of Immunosuppressive Agents to Prevent Neutralizing Antibodies Against a Transgene Product159
Part IV.Islet Isolation, Transplantation and the Bioartificial Pancreas
Potential Application of Neonatal Porcine Islets as Treatment for Type 1 Diabetes: A Review175
Clinical Islet Transplantation: A Review189
Islet Cryopreservation Protocols200
Bioartificial Pancreas: Alternative Supply of Insulin Secreting Cells208
Transplanation of Pancreatic Islets Contained in Minimal Volume Microcapsules in Diabetic High Mammalians219
Evaluation of Graft-Host Response for Various Tissue Sources and Animal Models233
Part V.Biological Aspects
Antigen Presentation Pathways for Immunity to Islet Transplants: Relevance to Immunoisolation255
Factors in Xenograft Rejection261
Encapsulated, Genetically Engineered Cells, Secreting Glucagon-like Peptide-1 for the Treatment of Non-Insulin-dependent Diabetes Mellitus277
Genetically Engineered Pancreatic [beta]-Cell Lines for Cell Therapy of Diabetes286
Re-engineering the Functions of a Terminally Differentiated Epithelial Cell in Vivo294
Reverse Engineering of Bioadhesion in Marine Mussels301
Part VI.Bioartificial Liver
Overview of Extracorporeal Liver Support Systems and Clinical Results310
Bioreactors for Hybrid Liver Support: Historical Aspects and Novel Designs326
Novel Bioartificial Liver Support System: Preclinical Evaluation340
Three-dimensional in Vitro Cell Culture Leads to a Marked Upregulation of Cell Function in Human Hepatocyte Cell Lines--An Important Tool for the Development of a Bioartificial Liver Machine353
Cultivation and Characterization of a New Immortalized Human Hepatocyte Cell Line HepZ for the Usage in an Artificial Liver Support System364
Part VII.Skin, Bone, Cartilage and Craniofacial Issues
rhBMP-Collagen Sponges as Osteoinductive Devices: Effects of in Vitro Sponge Characteristics and Protein pI on in Vivo rhBMP Pharmacokinetics369
Tissue Engineering of Bone in the Craniofacial Complex379
Computer Controlled Bioreactor for Large-scale Production of Cultured Skin Grafts386
A Method for Tissue Engineering of Cartilage by Cell Seeding on Bioresorbable Scaffolds398
Bioreactor Development for Tissue-Engineered Cartilage405
Index of Contributors413

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