Biochemistry of Lipids, Lipoproteins and Membranes / Edition 3
This is the third edition of this advanced textbook, written with two major objectives in mind. One is to provide an advanced textbook covering the major areas in the fields of lipid, lipoprotein, and membrane biochemistry, and molecular biology. The second objective is to provide a clear summary of these research areas for scientists presently working in these fields.
The volume provides the basis for an advanced course for students in the biochemistry of lipids, lipoproteins and membranes. The book will satisfy the need for a general reference and review book for scientists studying lipids, proteins and membranes. Excellent up-to-date reviews are available on the various topics covered. A current, readable, and critical summary of these areas of research, it will allow scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances.
Preface v List of contributors vii Functional roles of lipids in membranes William Dowhan Mikhail Bogdanov Eugenia Mileykovskaya 1 Lipid modifications of proteins Anant K. Menon 39 Fatty acid and phospholipid metabolism in prokaryotes Charles O. Rock 59 Lipid metabolism in plants Katherine M. Schmid John B. Ohlrogge 97 Oxidation of fatty acids in eukaryotes Horst Schulz 131 Fatty acid synthesis in eukaryotes Hei Sook Sul Stuart Smith 155 Fatty acid desaturation and chain elongation in mammals Makoto Miyazaki James M. Ntambi 191 Phospholipid biosynthesis in eukaryotes Dennis E. Vance Jean E. Vance 213 Ether-linked lipids and their bioactive species Thomas M. McIntyre Fred Snyder Gopal K. Marathe 245 Lipid metabolism in adipose tissue Ann V. Hertzel Brian R. Thompson Brian M. Wiczer David A. Bernlohr 277 Phospholipases David C. Wilton 305 The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways William L. Smith Robert C. Murphy 331 Sphingolipids Alfred H. Merrill, Jr. 363 Cholesterol biosynthesis Laura Liscum 399 Metabolism and function of bile acids Luis B. Agellon 423 Lipid assembly into cell membranes Dennis R. Voelker 441 Lipoprotein structure Ana Jonas Michael C. Phillips 485 Assembly and secretion of triacylglycerol-rich lipoproteins Jean E. Vance Khosrow Adeli 507 Dynamics of lipoprotein transport in the circulatory system Christopher J. Fielding Phoebe E. Fielding 533 Lipoprotein receptors Wolfgang J. Schneider 555 Lipids and atherosclerosis Ira Tabas 579 Subject Index 607