ISBN-10:
1441955836
ISBN-13:
9781441955838
Pub. Date:
08/05/2010
Publisher:
Springer New York
Biocompatible Polymeric Materials and Tourniquets for Wounds / Edition 1

Biocompatible Polymeric Materials and Tourniquets for Wounds / Edition 1

by Jan W. Gooch

Hardcover

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Product Details

ISBN-13: 9781441955838
Publisher: Springer New York
Publication date: 08/05/2010
Series: Topics in Applied Chemistry
Edition description: 2010
Pages: 184
Product dimensions: 6.10(w) x 9.20(h) x 0.60(d)

Table of Contents

1 Scope, Objectives, and Summary of Investigations 1

1.1 Scope and Objectives 1

1.2 Summary of Results 1

1.2.1 Barrier Dressing for Wounds 2

1.2.2 Bacteria Permeability of Dressing Materials 3

1.2.3 Antibacterial Aqueous Emulsions 4

1.2.4 One-Handed and Automatic Tourniquets 5

2 Barrier Dressings for Wounds 7

2.1 Introduction 7

2.1.1 Disinfection Fundamentals 14

2.1.2 Antimicrobial Agents and Disinfection 16

2.1.3 Mechanisms and Kinetics of Disinfection 16

2.2 Solvent-Based Polymer Barrier Dressings 17

2.2.1 Preparation 17

2.2.2 Formulation of Solvent-Based Dressings 18

2.2.3 Results of Testing Barrier Dressings on Rats 18

2.3 Polyacrylate Miniemulsions and Nonaqueous Suspensions 19

2.3.1 Miniemulsions 19

2.3.2 Nonaqueous Suspensions 24

2.4 Cyanoacrylate 27

2.4.1 Technical Discussion 27

2.5 Particulate Applied Barrier Dressing 32

2.5.1 Introduction 32

2.5.2 Copolymer Chemistry 33

2.5.3 Solution Polymers 34

2.5.4 Super Absorbent Fibers 34

2.5.5 Uses 34

2.5.6 Applications 35

2.5.7 Preparation 38

2.5.8 Reactive Mechanism 38

2.5.9 Dressing Preservative Agents 39

2.5.10 Results of Testing Barrier Dressing on Excised Rats 39

2.5.11 Reason for Failure to Provide Barrier Properties 40

2.6 Physical Properties of Barrier Dressing Materials 48

2.6.1 Results of Testing Barrier Dressings on Agar Plates 48

2.6.2 Surface Energy 48

2.6.3 Water Vapor Transmission 51

2.6.4 Dynamic Mechanical Analysis 53

2.6.5 Adhesion to Tissue 57

2.6.6 Removability of Barrier Dressing from Wounds 60

2.7 Bacteria Permeability of Dressings 60

2.8 Preservative and Antimicrobial Agents 65

2.9 Optimal Properties of Barrier Dressings 69

References 70

3 Tissue Adhesives 73

3.1 Introduction 73

3.2 Photopolymerizable Adhesives 74

3.2.1 Soft Gels 74

3.2.2 Hard Gels 78

3.3 Multicomponent Bonding Adhesives 79

3.3.1 Albumin/Glutaraldehyde Adhesive 79

3.3.2 Fibrin Glue 79

3.4 Single-Component Bonding Adhesives 80

3.4.1 Hydrogels 80

3.4.2 Dendrimers 80

3.4.3 Cyanoacryla te 81

3.4.4 Emulsion Polymerized Gel Adhesives 81

3.5 Review of Sutureless Adhesives from Literature 82

3.6 Testing the Bonding Properties on Soft Tissue 82

3.7 Summary of Tissue Bonding Adhesives 87

References 89

Further Reading 89

4 Antibacterial Aqueous Emulsions 91

4.1 Introduction 91

4.1.1 Literature 92

4.1.2 Patents 95

4.1.3 Preparation of Emsulsions 96

4.2 Testing Plan: Standard Sporicidal and Antibacterial Methods 97

4.2.1 Kirby-Bauer Plate Test (Disk Sensitivity Method) 97

4.2.2 Baker Suspension Test (Adapted) 99

4.3 Results of Testing 99

4.3.1 Kirby-Bauer Plates (Disk Sensitivity) Method 99

4.3.2 Baker Suspension (Dilution) Method 100

4.4 Novel Antimicrobial Emulsions and Particulate Formulations 102

4.4.1 Emulsification of Fatty Acids 102

4.4.2 Emulsified Fatty Acids and Antimicrobial Activity 103

4.4.3 Mechanisms of Antibacterial Action 106

4.4.4 Urea Hydrogen Peroxide 110

4.5 Summary 113

References 114

5 One-Hand Operated and Automatic Tourniquet 117

5.1 Introduction 117

5.2 Fundamentals of Tourniquet Technology 120

5.3 Critical Properties of a Combat Tourniquet 126

5.4 One-Hand Operated and Automatic Tourniquets for the Battlefield 134

5.5 Automatic Occlusion Pressure Controller 141

5.6 Summary 148

References 149

Recommended Literature 149

Index 179

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