Biological Effects of Polynucleotides: Proceedings of the Symposium on Molecular Biology, Held in New York, June 4-5, 1970 Sponsored by Miles Laboratories, Inc.

Biological Effects of Polynucleotides: Proceedings of the Symposium on Molecular Biology, Held in New York, June 4-5, 1970 Sponsored by Miles Laboratories, Inc.

Paperback(Softcover reprint of the original 1st ed. 1971)

$109.00
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Product Details

ISBN-13: 9783642857744
Publisher: Springer Berlin Heidelberg
Publication date: 04/10/2012
Edition description: Softcover reprint of the original 1st ed. 1971
Pages: 344
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

I Template Effects and Their Modification.- Qualitative and Quantitative Aspects of Polynucleotide Modification.- Template and Messenger Activities of Mutagen-Treated Polynucleotides.- Discussion.- II Interferon Stimulation.- Double-Stranded RNA’s in Relation to Interferon Induction and Adjuvant Activity.- Factors Affecting the Interferon Response of Mice to Polynucleotides.- Studies on the Anti-Tumor Action of Poly I: Poly C.- Molecular Requirements for Synthetic RNA to Act in Interferon Stimulation.- The Specificity of Interferon Induction.- Structural Requirements of Ribopolymers for Induction of Human Interferon: Evidence for Interferon Subunits.- Immunogenic Polynucleotides.- Discussion.- III Stimulation of Antibody Formation and Cell-Mediated Immunity.- Spectrum and Mode of Action of Poly A: U in the Stimulation of Immune Responses.- Stimulation of the Immune System by Homopolyribonucleotides.- Effect of Polynucleotides (Poly I · C and Poly A · U) on Protein, RNA, and Polysomal Synthesis in Rabbit and Human Lung, and Rat and Human Peritoneal Macrophages.- Conversion with Polynucleotides of a Genetically Controlled Low Immune Response to a High Response in Mice Immunized with a Synthetic Polypeptide Antigen.- Influence of Synthetic Polynucleotides on the Bactericidal Power of Mouse Macrophages against Listeria monocytogenes.- Remission Induction with Poly IC in Patients with Acute Lymphoblastic Leukemia (Preliminary Results).- Immunity and Tolerance to Synthetic Polynucleotides in New Zealand Mice.- Discussion.- IV Pharmacological Aspects of Polynucleotide Effects.- The Double-Bitted Axe: A Study of Toxicity of Interferon Releasers.- Polyinosinic-Polycytidylic Acid Toxicity.- Discussion.- V Polynucleotide-Associated Events in Immunocompetent Cells.- Cell to Cell Cooperation in the Immune Response: A Role for Macrophage RNA-Antigen Complexes?.- Antigen Capture by a Unique Ribonucleoprotein of Macrophage Cells.- Observations on the Regulatory Effects of the Transfer RNA Minor Base, N6-?2-(Isopentenyl)Adenosine, on Human Lymphocytes.- Discussion.

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