The twenty-one chapters of this volume comprise the report of the Dahlem Workshop on Biological Perspectives of Schizophrenia held in Berlin, October 1986. Contributors examine biological processes involved in the etiology and pathenogenesis of schizophrenia, define gaps in our knowledge thereof, and indicate directions for future work. Topics covered include genetic factors (possible markers and new strategies), non-genetic factors (brain diseases, obstetrical complications, viral infections, and autoimmune processes), as well as structural factors (neuromorphometric and brain imaging findings and structural deviations). The reader will find arguments pro and con for the future significance of genetic linkage studies versus association studies, the potential role of SPEM disturbances, the retrovirus/transposon hypothesis, the rCBF hypofrontality phenomenon, and the significance of both anatomical and functional deviations in limbic structures.
Table of Contents
Partial table of contents:
GENETICS AS AN APPROACH TO ETIOLOGY.
''The Middle Game'' in the Genetics of Schizophrenia (S. Matthysse).
The Feasibility of Linkage Studies in Schizophrenia (K. Kendler).
The Contribution of Genetic Research to Diagnostic Issues in Schizophrenia (M. Tsuang et al.).
NONGENETIC ETIOLOGICAL FACTORS.
The Scope for Nongenetic Factors in Etiology: The Retrovirus/Transposon Hypothesis (T. Crow).
Organic and Toxic Concomitants of Schizophrenia: Association or Chance?
STRUCTURAL AND FUNCTIONAL DEVIATIONS.
In Vivo and Postmortem Evidence of Structural Changes (E. Johnstone).
Evidence for Frontal/Prefrontal Cortical Schizophrenia: The Phenomenon of ''Hypofrontality'' Reconsidered (D. Ingvar).
Midbrain Dopamine System Heterogeneity: Implications for Schizophrenia (B. Bunney).
Overview of Dopamine Mechanisms: Neurochemical and Pharmacological Evidence (A. Carlsson).
Clinical Studies of Antipsychotic Agents: Implications for Neurotransmitter Mechanisms (J. Kane).