Biologically Based Methods for Cancer Risk Assessment

Biologically Based Methods for Cancer Risk Assessment

by Curtis Travis (Editor)

Paperback(Softcover reprint of the original 1st ed. 1989)

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Product Details

ISBN-13: 9781468456271
Publisher: Springer US
Publication date: 04/30/2013
Series: Nato Science Series A: , #159
Edition description: Softcover reprint of the original 1st ed. 1989
Pages: 355
Product dimensions: 7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

Research Needs for Biologically Based Risk Assessment.- Biological Bases for Cancer Models.- Multistage Models for Cancer Risk Assessment.- Understanding Multi-Stage Carcinogenesis at the Molecular Level: Notes on Recent Progress.- The Use of Enzyme-Altered Foci for Risk Assessment of Hepatocarcinogens.- Pathogenic Interrelationship of Focal Lesions, Nodules, Adenomas and Carcinomas in the Multistage Evolution of Azaserine-Induced Rat Pancreas Carcinogenesis.- Phenotypic Cellular Changes in Multistage Carcinogenesis.- Interspecies Extrapolation of Pharmacokinetics.- Interspecies Extrapolation.- Comparative Carcinogenesis: Is There a Theoretical Approach to Inter-Species Similarity.- Biological Basis for Interspecies Extrapolations of Halogenated Solvents and of 1,3-Butadiene.- Species-Specific Inhalation Pharmacokinetics of 2-Nitropropane, Methyl Ethyl Ketone, and n-Hexane.- Promotion as a Factor in Carcinogenesis.- Overview of Promotion as a Mechanism in Carcinogenesis.- Hepatocarcinogenesis by Non-Genotoxic Compounds.- The Role of Inhibited Intercellular Communication in Carcinogenesis: Implications for Risk Assessment From Exposure to Chemicals.- Comparative Analyses of the Timing and Magnitude of Genotoxic and Nongenotoxic Cellular Effects in Urinary Bladder Carcinogenesis.- Alterations in Gene Expression in Mouse Hepatocarcinogenesis.- Screening for Carcinogenesis.- Medium-Term Bioassay Models for Environmental Carcinogens — Two — Step Liver and Multi-Organ Carcinogenesis Protocols.- The Use of Aldh Induction as a Carcinogenic Risk Marker in Comparison With Typical in Vitro Mutagenicity System.- Expression of Inducible Cytochrome P-450 mRNAs During Promotion of Expermential Chemical Hepatocarcinogenesis.- An In Vitro Approach for Interspecies Extrapolation Using Animal and Human Airway Epithelial Cell Culture.- Cancer Risk Assessment.- Assement of Low-Exposure Risk from Carcinogens: Implications of the Knudson-Moolgavkar Two-Critical Mutation Theory.- A Biological Data Base for Methylene Chloride Risk Assessment.- Computer Simulation of Chemical Carcinogenesis.- Determination of Carcinogen Exposure by Immunological Techniques.- Risk Estimation for Leukemogenic Drugs.- Contributors.

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