This major new volume describes the recent discoveries in this field, including the implications of the recognition of specific components o f the innate immunity arsenal as the main cause of host susceptibility to particular types of infections, and the development of new agents to combat infections using newly identified anti-microbial peptides. T here is also coverage of the major themes, such as (i) the role of inn ate immune responses as a first-line defense against microbial infecti on and tumor cells; (ii) the cellular and molecular basis of the funct ion of cells and molecules involved in innate immunity; (iii) the role of innate immunity in the immunocompromised host; and (iv) the intera ctions between innate immunity components and clonal immune response.
Table of Contents
Preface. I: Pattern Recognition, Receptors and Collectins in Innate Immunity. 1. Mannose receptor and scavenger receptor: two macrophage pattern recognition receptors with diverse functions in tissue homeostasis and host defense; S.A. Linehan, et al. 2. Complement receptor 3 (CR3): a public transducer of innate immunity signals in macrophages; E. Yefenof. 3. The role of C-type lectins in the innate immunity against pulmonary pathogens; I. Ofek, et al. 4. Modulation of nitric oxide production by lung surfactant in alveolar macrophages; M. Kalina, et al. 5. Development of chimeric collectins with enhanced activity against influenza A virus; K. Hartshorn, et al. 6. Initial steps in Strepoccus pneumoniae interaction with and pathogenicity to the host; M. Shani-Sekler, et al. II: Host Cells and Cytokines in Innate Immunity. 7. Role of cytokines in the maturation and function of macrophages: effect of GM-CSF and IL-4; Y. Keisari, et al. 8. Mast cell modulation of the innate immune response to enterobacterial infection; S.N. Abraham, R. Malaviya. 9. The NADPH oxidase diaphorase activity in permeabilized human neutrophils and granulocytic like PLB-985 cells; I. Pessach, R. Levy. 10. Activation of cytosolic phospholipase A2 by opsonized zymosan in human neutrophils requires both ERK and p38 MAP-kinase; I. Hazan-Halevy, R. Levy. 11. Cytosolic phospholipase A2 is required for the activation of the NADPH oxidase associated H+ channel in phagocyte-like cells; R. Levy, et al. 12. The role of NK cells in innate immunity; N. Lieberman, O. Mandelboim. 13. Similarities and dissimilarities between humans and mice looking at adhesion molecules efects; A. Etzioni, et al. 14. The role of dendritic cells at the early stages of Leishmania infection; H. Moll. 15. DNA-based vaccines: role of dendritic cells in antigen presentation; L. Paul, A. Porgador. 16. Distinct patterns of IL-1α and IL-1β organ distribution – a possible basis for organ mechanisms of innate immunity; M. Hacham, et al. III: Antimicrobial Peptides. 17. Structure and biology of cathelicidins; M. Zanetti, et al. 18. Structure activity relationship study of polymyxin B nonapeptide; H. Tsubery, et al. IV: Innate Immunity in the Compromised Host. 19. The clinical significance of neutrophil dysfunction; B. Wolach, et al. 20. Clinical significance of function aberrations in macrophages and NK cells, in type-1 cytokines and in lectin-binding molecules; Z. Handzel. 21. Klebsiella infections in the immunocompromised host; H. Sahly, et al. V: Innate Immunity Components in Cancer. 22. Macrophage – recognized molecules of apoptotic cells are expressed at higher level in AKR lymphoma of aged as compared to young mice; O. Itzhaki, et al. 23. Sensitivity to macrophages decreases with tumor progression in the AKR lymphoma; T. Kaptzan, et al. 24. Opposing effects of IL-1α and IL-1β on malignancy patterns; tumor cell-associated IL-1α potentiates anti-tumor immune responses and tumor regression, whereas IL-1β potentiates invasiveness; R.N. Apte, et al.