The Biology and Pathology of Innate Immunity Mechanisms

The Biology and Pathology of Innate Immunity Mechanisms


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The Biology and Pathology of Innate Immunity Mechanisms by Yona Keisari

This major new volume describes the recent discoveries in this field, including the implications of the recognition of specific components o f the innate immunity arsenal as the main cause of host susceptibility to particular types of infections, and the development of new agents to combat infections using newly identified anti-microbial peptides. T here is also coverage of the major themes, such as (i) the role of inn ate immune responses as a first-line defense against microbial infecti on and tumor cells; (ii) the cellular and molecular basis of the funct ion of cells and molecules involved in innate immunity; (iii) the role of innate immunity in the immunocompromised host; and (iv) the intera ctions between innate immunity components and clonal immune response.

Product Details

ISBN-13: 9781475786477
Publisher: Springer US
Publication date: 03/26/2013
Series: Advances in Experimental Medicine and Biology , #479
Edition description: 2002
Pages: 330
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Preface. I: Pattern Recognition, Receptors and Collectins in Innate Immunity. 1. Mannose receptor and scavenger receptor: two macrophage pattern recognition receptors with diverse functions in tissue homeostasis and host defense; S.A. Linehan, et al. 2. Complement receptor 3 (CR3): a public transducer of innate immunity signals in macrophages; E. Yefenof. 3. The role of C-type lectins in the innate immunity against pulmonary pathogens; I. Ofek, et al. 4. Modulation of nitric oxide production by lung surfactant in alveolar macrophages; M. Kalina, et al. 5. Development of chimeric collectins with enhanced activity against influenza A virus; K. Hartshorn, et al. 6. Initial steps in Strepoccus pneumoniae interaction with and pathogenicity to the host; M. Shani-Sekler, et al. II: Host Cells and Cytokines in Innate Immunity. 7. Role of cytokines in the maturation and function of macrophages: effect of GM-CSF and IL-4; Y. Keisari, et al. 8. Mast cell modulation of the innate immune response to enterobacterial infection; S.N. Abraham, R. Malaviya. 9. The NADPH oxidase diaphorase activity in permeabilized human neutrophils and granulocytic like PLB-985 cells; I. Pessach, R. Levy. 10. Activation of cytosolic phospholipase A2 by opsonized zymosan in human neutrophils requires both ERK and p38 MAP-kinase; I. Hazan-Halevy, R. Levy. 11. Cytosolic phospholipase A2 is required for the activation of the NADPH oxidase associated H+ channel in phagocyte-like cells; R. Levy, et al. 12. The role of NK cells in innate immunity; N. Lieberman, O. Mandelboim. 13. Similarities and dissimilarities between humans and mice looking at adhesion molecules efects; A. Etzioni, et al. 14. The role of dendritic cells at the early stages of Leishmania infection; H. Moll. 15. DNA-based vaccines: role of dendritic cells in antigen presentation; L. Paul, A. Porgador. 16. Distinct patterns of IL-1α and IL-1β organ distribution – a possible basis for organ mechanisms of innate immunity; M. Hacham, et al. III: Antimicrobial Peptides. 17. Structure and biology of cathelicidins; M. Zanetti, et al. 18. Structure activity relationship study of polymyxin B nonapeptide; H. Tsubery, et al. IV: Innate Immunity in the Compromised Host. 19. The clinical significance of neutrophil dysfunction; B. Wolach, et al. 20. Clinical significance of function aberrations in macrophages and NK cells, in type-1 cytokines and in lectin-binding molecules; Z. Handzel. 21. Klebsiella infections in the immunocompromised host; H. Sahly, et al. V: Innate Immunity Components in Cancer. 22. Macrophage – recognized molecules of apoptotic cells are expressed at higher level in AKR lymphoma of aged as compared to young mice; O. Itzhaki, et al. 23. Sensitivity to macrophages decreases with tumor progression in the AKR lymphoma; T. Kaptzan, et al. 24. Opposing effects of IL-1α and IL-1β on malignancy patterns; tumor cell-associated IL-1α potentiates anti-tumor immune responses and tumor regression, whereas IL-1β potentiates invasiveness; R.N. Apte, et al.

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