This comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives.
This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Biology of Stem Cell Niche is an ideal complementary volume to Tissue-Specific Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.
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Table of Contents
.-1 The Hematopoietic Stem Cell Niche: Cell-Cell Interactions and Quiescence
.-2THE MAMMALIAN LIMBAL STEM CELL NICHE: A COMPLEX INTERACTION BETWEEN CELLS, GROWTH FACTORS AND EXTRACELLULAR MATRIX
.-3 Emerging Engineering Strategies for Studying the Stem Cell Niche
.-4 Bioreactors and the Design of the Stem Cell Niche
.-5 Stem Cell Niche-Radiobiological Response
.-6 Impact of radiation on hematopoietic niche
.-7 From neurogenic niche to site of injury: stem cell-mediated biobridge for brain repair
.-8 Using Stem Cells to Promote Wound Healing: an Emerging Solution for a Clinical Problem
.-9 Cancer Stem Cell Niche
.- 10 Insight into Cancer Stem Cell Niche; Lessons from Cancer Stem Cell Models Generated in vitro