Traditionally, oligodendrocytes have been considered to play a minor supporting role in the central nervous system and their importance has generally been ignored. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of its primary function, myelin synthesis and maintenance, in neural disease and repair. Particular attention is paid to multiple sclerosis, arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in multiple sclerosis lesions.
|Publisher:||Cambridge University Press|
|Product dimensions:||6.00(w) x 9.00(h) x 0.70(d)|
About the Author
Emily Mathey is a postdoctoral scientist at the Brain and Mind Research Institute at the University of Sydney. She has a keen interest in both immunology and neurobiology with particular emphasis on pathogenic antibody responses in demyelinating disease of the peripheral and central nervous systems.
Table of Contents
1 CNS oligarchs; the rise of the oligodendrocyte in a neuron-centric culture Emily K. Mathey Ariel Arthur Patricia J. Armati 1
2 Comparative biology of Schwann cells and oligodendrocytes Rudolf Martini Janos Groh Udo Bartsch 19
3 Control of oligodendrocyte development and myelination in the vertebrate CNS Robert H. Miller 49
4 Molecular organization of the oligodendrocyte and myelin Grahame Kidd Bruce D. Trapp 64
5 The genetics of oligodendrocytes Joseph A. Nielsen Pierre Lau Lynn D. Hudson 103
6 Immunobiology of the oligodendrocyte David Kremer Orhan Aktas Hans-Peter Hartung Patrick Küry 115
7 Oligodendrocytes and disease: repair, remyelination and stem cells Neil J. Scolding 137
8 Glial progenitor cells and the dynamics of the oligodendrocyte and its myelin in the aged and injured CNS Jurate Lasiene Philip J. Horner 154
9 Oligodendroglial pathology in multiple sclerosis Tanja Kuhlmann Wolfgang Brück 171
10 Glutamate receptors, transporters and periventricular leukomalacia Tara M. Desilva Paul A. Rosenberg 186