ISBN-10:
0130097101
ISBN-13:
9780130097101
Pub. Date:
01/16/2008
Publisher:
Pearson
Biomaterials: The Intersection of Biology and Materials Science / Edition 1

Biomaterials: The Intersection of Biology and Materials Science / Edition 1

by Johnna S. Temenoff, Antonios G. Mikos

Hardcover

View All Available Formats & Editions
Current price is , Original price is $232.2. You
Select a Purchase Option (New Edition)
  • purchase options
    $54.10 $232.20 Save 77% Current price is $54.10, Original price is $232.2. You Save 76.70111972437554%.
    • Free return shipping at the end of the rental period details
    • Textbook Rentals in 3 Easy Steps  details
    icon-error
    Note: Access code and/or supplemental material are not guaranteed to be included with textbook rental or used textbook.
  • purchase options
    $215.52 $232.20 Save 7% Current price is $215.52, Original price is $232.2. You Save 7%.
  • purchase options
    $118.53 $232.20 Save 49% Current price is $118.53, Original price is $232.2. You Save 49%.
    icon-error
    Note: Access code and/or supplemental material are not guaranteed to be included with textbook rental or used textbook.
  • purchase options

Overview

Biomaterials: The Intersection of Biology and Materials Science / Edition 1

Intended for use in an introductory course on biomaterials, taught primarily in departments of biomedical engineering. The book covers classes of materials commonly used in biomedical applications, followed by coverage of the biocompatibility of those materials with the biological environment. Finally, it covers some in-depth applications of biomaterials. It does all of this with an overall emphasis on tissue engineering.

Product Details

ISBN-13: 9780130097101
Publisher: Pearson
Publication date: 01/16/2008
Series: Pearson Prentice Hall Bioengineering Ser.
Edition description: New Edition
Pages: 504
Sales rank: 214,222
Product dimensions: 8.20(w) x 10.00(h) x 0.90(d)

About the Author

Johnna S. Temenoff and Antonios G. Mikos, co-authors of Biomaterials: The Intersection of Biology and Materials Science, have been chosen to receive the 2010 Meriam/Wiley Distinguished Author Award from the American Society for Engineering Education (ASEE). This marks the first time that authors of a biomedical engineering textbook have been recognized with this award.

Table of Contents

Chapter 1: Materials for Biomedical Applications 1-1

1.1. Introduction to biomaterials 1-2

1.2. Biological response to biomaterials 1-8

1.3. Biomaterial product testing and FDA approval 1-10

1.4. Types of biomaterials 1-11

1.5. Processing of biomaterials 1-15

1.6. Important properties of biomaterials 1-16

1.7. Principles of chemistry 1-21

1.8. Summary 1-35

1.9. Problems 1-37

1.10. Tables 1-39

1.11. Figures 1-44

1.12. References 1-70

1.13. Additional reading 1-72

Chapter 2: Chemical Structure of Biomaterials 2-1

2.1. Introduction: Bonding and the structure of biomaterials 2-2

2.2. Structure of Metals 2-2

2.3. Structure of Ceramics 2-18

2.4. Structure of polymers 2-24

2.5. Techniques: Introduction to material characterization 2-41

2.6. Summary 2-62

2.7. Problems 2-64

2.8. Tables 2-69

2.9. Figures 2-79

2.10. References 2-148

2.11. Additional reading 2-149

Chapter 3: Physical Properties of Biomaterials 3-1

3.1. Introduction: From atomic groupings to bulk materials 3-2

3.2. Crystallinity and linear defects 3-2

3.3. Crystallinity and planar defects 3-8

3.4. Crystallinity and volume defects 3-12

3.5. Crystallinity and polymeric materials 3-13

3.6. Thermal transitions of crystalline and non-crystalline materials 3-18

3.7. Techniques: Introduction to Thermal Analysis 3-26

3.8. Summary 3-30

3.9. Problems 3-32

3.10. Tables 3-35

3.11. Figures 3-38

3.12. References 3-63

3.13. Additional reading 3-64

Chapter 4: Mechanical Properties of Biomaterials 4-1

4.1. Introduction: Modes of mechanical testing 4-3

4.2. Mechanical testing methods, results and calculations 4-3

4.3. Fracture and failure 4-40

4.4. Fatigue and fatigue testing 4-43

4.5. Methods to improve mechanical properties 4-46

4.6. Techniques: Introduction to Mechanical Analysis 4-49

4.7. Summary 4-51

4.8. Problems 4-54

4.9. Figures 4-58

4.10. References 4-101

4.11. Additional reading 4-101

Chapter 5: Biomaterial Degradation 5-1

5.1. Introduction: Degradation in the biological environment 5-2

5.2. Corrosion/degradation of metals and ceramics 5-3

5.3. Degradation of polymers 5-18

5.4. Biodegradable materials 5-22

5.5. Techniques: Assays for extent of degradation 5-29

5.6. Summary 5-30

5.7. Problems 5-32

5.8. Tables 5-37

5.9. Figures 5-40

5.10. References 5-54

5.11. Additional reading 5-55

Chapter 6: Biomaterial Processing 6-1

6.1. Introduction: Importance of biomaterials processing 6-2

6.2. Processing to improve bulk properties 6-2

6.3. Processing to form desired shapes 6-12

6.4. Processing to improve biocompatibility 6-26

6.5. Summary 6-30

6.6. Problems 6-32

6.7. Tables 6-34

6.8. Figures 6-35

6.9. References 6-54

6.10. Additional reading 6-55

Chapter 7: Surface Properties of Biomaterials 7-1

7.1. Introduction: Concepts in surface chemistry and biology 7-2

7.2. Physicochemical surface modification techniques 7-6

7.3. Biological surface modification techniques 7-20

7.4. Surface properties and degradation 7-25

7.5. Patterning techniques for surfaces 7-25

7.6. Techniques: Introduction to surface characterization 7-27

7.7. Summary 7-46

7.8. Problems 7-48

7.9. Tables 7-53

7.10. Figures 7-58

7.11. References 7-107

7.12. Additional reading 7-109

Chapter 8: Protein Interactions with Biomaterials 8-1

8.1. Introduction: Thermodynamics of protein adsorption 8-2

8.2. Protein structure 8-7

8.3. Protein transport and adsorption kinetics 8-15

8.4. Reversibility of protein adsorption 8-18

8.5. Techniques: Assays for protein type and amount 8-22

8.6. Summary 8-33

8.7. Problems 8-35

8.8. Tables 8-39

8.9. Figures 8-42

8.10. References 8-74

8.11. Additional reading 8-75

Chapter 9: Cell Interactions with Biomaterials 9-1

9.1. Introduction: Cell-surface interactions and cellular functions 9-2

9.2. Cellular structure 9-3

9.3. Extracellular environment 9-14

9.4. Cell-environment interactions affect cellular functions 9-23

9.5. Models of adhesion, spreading and migration 9-34

9.6. Techniques: Assays to determine effects of cell-material interactions 9-43

9.7. Summary 9-53

9.8. Problems 9-57

9.9. Tables 9-61

9.10. Figures 9-62

9.11. References 9-113

9.12. Additional reading 9-115

Chapter 10: Biomaterial Implantation and Acute Inflammation 10-1

10.1. Introduction: Overview of innate and acquired immunity 10-2

10.2. Clinical signs of inflammation and their causes 10-5

10.4. Role of other granulocytes 10-11

10.5. Termination of acute inflammation 10-16

10.6. Techniques: In vitro assays for inflammatory response 10-17

10.7. Summary 10-20

10.8. Problems 10-22

10.9. Tables 10-24

10.10. Figures 10-27

10.11. References 10-34

10.12. Additional reading 10-34

Chapter 11: Wound Healing and the Presence of Biomaterials 11-1

11.1. Introduction: Formation of granulation tissue 11-2

11.2. Foreign body reaction 11-3

11.3. Fibrous encapsulation 11-4

11.4. Chronic inflammation 11-7

11.5. Four types of resolution 11-8

11.6. Repair vs. regeneration: wound healing in skin 11-9

11.7. Techniques: In vivo assays for inflammatory response 11-12

11.8. Summary 11-20

11.9. Problems 11-22

11.10. Tables 11-25

11.11. Figures 11-28

11.12. References 11-36

11.13. Additional reading 11-37

Chapter 12: Immune Response to Biomaterials 12-1

12.1. Introduction: Overview of acquired immunity 12-2

12.2. Antigen presentation and lymphocyte maturation 12-4

12.3. B cells and antibodies 12-8

12.4. T cells 12-12

12.5. The complement system 12-14

12.6. Undesired immune responses to biomaterials 12-19

12.7. Techniques: Assays for immune response 12-25

12.8. Summary 12-28

12.9. Problems 12-32

12.10. Tables 12-34

12.11. Figures 12-35

12.12. References 12-51

12.13. Additional reading 12-51

Chapter 13: Biomaterials and Thrombosis 13-1

13.1. Introduction: Overview of hemostasis 13-2

13.2. Role of platelets 13-2

13.3. Coagulation cascade 13-5

13.4. Means of limiting clot formation 13-9

13.5. Role of endothelium 13-11

13.6. Tests for hemocompatibility 13-13

13.7. Summary 13-18

13.8. Problems 13-20

13.9. Tables 13-25

13.10. Figures 13-27

13.11. References 13-32

13.12. Additional reading 13-33

Chapter 14: Infection, Tumorigenesis and Calcification of Biomaterials 14-1

14.1. Introduction: Overview of other potential problems with biomaterials implantation 14-2

14.2. Infection 14-2

14.3. Techniques for infection experiments 14-10

14.4. Tumorigenesis 14-16

14.5. Techniques for tumorigenesis experiments 14-21

14.6. Pathologic calcification 14-23

14.7. Techniques for pathologic calcification experiments 14-26

14.8. Summary 14-30

14.9. Problems 14-33

14.10. Figures 14-36

14.11. References 14-45

14.12. Additional reading 14-46

List of Abbreviations Appendix I-1

List of Symbols Appendix I-6

Index Index

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews