ISBN-10:
3527308075
ISBN-13:
9783527308071
Pub. Date:
04/02/2004
Publisher:
Wiley
Biomedical Applications of Proteomics / Edition 1

Biomedical Applications of Proteomics / Edition 1

Hardcover

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Product Details

ISBN-13: 9783527308071
Publisher: Wiley
Publication date: 04/02/2004
Pages: 452
Product dimensions: 6.93(w) x 9.76(h) x 1.07(d)

About the Author

Jean-Charles Sanchez has been working since 1989 in thefield of proteomics. He contributed in the development oftwo-dimensional polyacrylamide gel electrophoresis and relatedprocedures and their application in Biomaker discovery research. Heobtained his Ph.D. in Biochemistry at the Buckingham University(UK) and in 1997 a Business Administration diploma (Officer Schoolof Lausanne). Since 1995, he has been the head of the BiomedicalProteoomics Group at the BPRG at the Geneva University Hospital. Heis a founder of the Swiss Proteomics Society, Swiss-2Dservice andPhenomics Sciences Consulting. The activities in his group coverthe discovery of new disease markers and drug targets inmulti-factorial disorders including cancer, Alzheimer, CJD, stoke,obesity and type II diabetes.

Garary L. Corthals has been involved in proteomics forover 10 years and has focused on integrating MS technologies forprotein analysis in biomedical research. His current interestsinclude development of technologies for rapid and sensitive proteinanalysis to discover new diagnostic markers for disease and toelucidate cellular processes that direct physiological behaviour.Other activities include the synthesis of new chemistries foraccurate quantitation or proteins and the concurrent analysis ofPTMs; as well as technologies for capturing high density proteinprofiles. He obtained his Ph.D. in Biology at Macquarie University(Australia) in the field of proteomics. Before arriving in Genevahe worked in the Department of Molecular Biotechnology (UW,Seattle) and directed the Proteomics Facility at the GarvanInstitute of Medical Research in Sydney (Australia). He currentlyheads the MS Group at the BPRG at Geneva University Hospital and isco-director of the Proteomics Facility of the Faculty ofMedicine.

Denis F. Hochstrasser is the director of the ClinicalPathology Department and Head of the Clinical Chemistry Laboratoryof the Geneva University Hospital. He obtained his M.D. at GenevaMedical School, and did his internship and residency at UNC, ChapelHill (USA). He is known for his pioneering development of what isnow called proteomics. He initiated work on software developmentfor proteomics data processing 15 years ago and has contributed tothe development of the leading 2-D gel analysis software Melaineand related 2-D-PAGE database. He was instru-mental the creation ofExPASy, the fist life sciences devoted web server. Most recently hehas been responsible for the Molecular Scanner, a technique thatpromises to enhance clinical proteomic analysis. He is a founder ofthe Swiss Institute for Bioinformatics and scientific founder ofGeneProt & GeneBio.

Table of Contents

Preface
SECTION I: ASPECTS OF BIOMEDICAL RESEARCH
Proteomics in Biomedicine -
A Tool, a Science or an Art?
SECTION II: BLOOD VESSELS
Antibody-Based Vascular Targeting: Proteomic Techniques for the Identification and Quantitation of Membrane Proteins on Endothelial Cells
Vasculature, Vascular Disease and Atherosclerosis
Discovery of New Diagnostic Markers of Stroke
SECTION III: CANCER
Unravelling Biological Pathways and the Identification of Clinical Markers and Targets in Renal Cancer
HSP27 in Cancer
Proteomic Approaches for Biomarker Discovery in Colorectal Cancer
Clinical Proteomics: Ovarian Cancer
Protein Expression Profiling Analysis in Hematopoietic Stem Cells: Phenotypic Characterization of Mesenchymal Stem Cells
Lymphoblastoid and Lymphoma Cells
SECTION IV: PHARMACO-TOXICOLOGY
Chemoresistance in Cancer Cells
Diabetes Mellitus: Complex Molecular Alterations)
SECTION V: INFECTIOUS DISEASES
Proteome Approach to Infectious Diseases
New Insights Into HIV Lymphocyte Infection
Modifications of Host-Cell Proteomes Induced by Herpes Virus Type 1
Francisella Tularensis
SECTION VI: CENTRAL NERVOUS SYSTEM
Proteomics in Clinical Neurosciences
Human Cerebrospinal Fluid
Proteomic Applications for Molecular Assessment of Alzheimer's Disease
SECTION VII: MASS SPECTROMETRY AND BIOINFORMATICS
MALDI MS Imaging in Biomedical Research
Protein Variations: Resources and Tools

What People are Saying About This

From the Publisher

"In spite of the complexity of many diseases as well as proteomicapproaches that may be applied, the style of the book is generallyclear and straightforward in its presentation."
--Hana Kovarova, Academy of Sciences of the Czech Republic,Proteomics, Wiley-VCH

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