Here's the first state-of-the-art design reference on artificial implant surfaces. It takes you to the cutting-edge of efforts to understand and control the constant interactions taking place between biomaterials and biological media. The book explores processes and surface modifications that occur in various bio/non bio interfaces, and provides the latest performance-enhancing design, materials selection, and manufacturing guidance including nanotechnology breakthroughs that are ushering in a new age of biomaterial design and applications. After an extensive discussion of biomedical surfaces attributes, the book addresses design issues that arise where materials and biofluids interface and the suppression or selective adsorption of biomacromolecules is a key objective. Implant lubrication and wear issues are covered, including adsorption of lubricants on surfaces and the tribology of the surfaces themselves. The book explores interaction issues crucial to predicting biomaterial interactions with body tissues, including protein adsorption and desorption processes, immune cell response, the assimilation and interaction of cells like osteocytes, and bacterial infection risks, and includes a chapter on biomedical surfaces manufacturing which emphasizes practical design issues. The volume also examines emerging nano-engineered materials including smart surfaces that are responsive to host cells and tissues, as well as novel drug delivery surfaces developed with nano- and microtechnologies. Complete with techniques for measuring surface properties, this well-illustrated resource helps you design or select implants that deliver ever-higher levels of performance and durability.
About the Author
Jeremy Ramsden is a professor of nanotechnology in the Materials Department of Cranfield University, United Kingdom. He has published over 100 research articles covering topics in adsorption and desorption, biological macromolecules, and self-assembly and organizing processes at the nanoscale, and has chaired several international conferences devoted to biomolecular interactions. He is editor-in-chief of the Journal of Biological Physics and Chemistry, and founder of the MEMOCS research consortium uniting a dozen academic research groups and industrial firms in developing integrated-optical membrane-based sensors for medical and environmental applications. Dr. Ramsden studied Natural Sciences at Cambridge University and received his Ph.D. from the Institute of Chemical Physics, Swiss Federal Institute of Technology in Lausanne.
Table of Contents
Introduction. The Adsorption of (Bio)macromolecules. Haemocompatibility. Lubrication. Cells and Tissues. Drug Delivery Surfaces. Prospects for Smart and Nano Materials.