Bionano Concise Monographs Series - New Volume 13: Mechanical Blood Trauma in Circulatory-Assist Devices

Bionano Concise Monographs Series - New Volume 13: Mechanical Blood Trauma in Circulatory-Assist Devices

Hardcover

$89.95

Product Details

ISBN-13: 9780791860397
Publisher: American Society of Mechanical Engineers
Publication date: 03/28/2015
Product dimensions: 6.10(w) x 9.10(h) x 0.40(d)

Table of Contents

Guest Editors' Preface iii

Series Editors' Preface v

Abstract ix

1 Introduction 1

2 Hemolysis 3

3 Testing blood trauma in circulatory assist devices 5

3.1 Historical overview 5

3.2 Mechanical stresses which produce high levels of hemolysis 6

4 Sublethal blood trauma 9

4.1 Effect of mechanical stress on RBC deformability 11

4.2 Effect of mechanical stress on RBC aggregation 13

4.3 Mechanical fragility of red blood cells 16

5 Damage to leukocytes 19

5.1 Thrombosis and bleeding 19

5.1.1 In vitro studies of the mechanical stress effects on platelets 21

6 In vitro testing devices for blood biocompatibility 23

6.1 Methods of plasma free Hb measurement 25

6.1.1 OxyHb absorbency at 540 nm 25

6.1.2 Cripps method 25

6.2 Normalised Index of Hemolysis 26

7 Clinical issues and experience 27

7.1 Sequelae from hemolysis 27

7.2 Hemoglobin-haptoglobin complex 27

7.3 Effect of free Hb on platelets 29

7.4 Historical review of devices and resultant hemolysis issues 29

7.5 Surgical approaches to limit hemolysis 32

8 Medical therapy elevated plasma free hemoglobin 35

9 Concluding remarks 37

10 References 39

11 Author biographies 51

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