This book provides detailed reviews of a range of nanostructures used in the construction of biosensors as well as the applications of these biosensor nanotechnologies in the biological, chemical, and environmental monitoring fields
Biological sensing is a fundamental tool for understanding living systems, but also finds practical application in medicine, drug discovery, process control, food safety, environmental monitoring, defense, and personal security. Moreover, a deeper understanding of the bio/electronic interface leads us towards new horizons in areas such as bionics, power generation, and computing. Advances in telecommunications, expert systems, and distributed diagnostics prompt us to question the current ways we deliver healthcare, while robust industrial sensors enable new paradigms in R&D and production.
Despite these advances, there is a glaring absence of suitably robust and convenient sensors for body chemistries. This book examines some of the emerging technologies that are fueling scientific discovery and underpinning new products to enhance the length and quality of our lives.
The 14 chapters written by leading experts cover such topics as:
- ZnO and graphene microelectrode applications in biosensing
- Assembly of polymers/metal nanoparticles
- Gold nanoparticle-based electrochemical biosensors
- Impedimetric DNA sensing employing nanomaterials
- Graphene and carbon nanotube-based biosensors
- Computational nanochemistry study of the BFPF green fluorescent protein chromophore
- Biosynthesis of metal nanoparticles
- Bioconjugated-nanoporous gold films in electrochemical biosensors
- The combination of molecular imprinting and nanotechnology
- Principles and properties of multiferroics and ceramics
About the Author
Ashutosh Tiwari is an Associate Professor at theBiosensors and Bioelectronics Centre, Linköping University,Sweden; Editor-in-Chief, Advanced Materials Letters;Secretary General, International Association of Advanced Materials;a materials chemist and also a docent in applied physics atLinköping University, Sweden. He has published more than 350articles, patents, and conference proceedings in the field ofmaterials science and technology and has edited/authored more thanfifteen books on the advanced state-of-the-art of materialsscience. He is a founding member of the Advanced Materials WorldCongress and the Indian Materials Congress.
Anthony P.F. Turner is currently Head of DivisionFM-Linköping University’s new Centre for Biosensors andBioelectronics. His previous thirty-five year academic career inthe UK culminated in the positions of Principal (Rector) ofCranfield University and Distinguished Professor of Biotechnology.Professor Turner has more than 600 publications and patents in thefield of biosensors and biomimetic sensors and is best known forhis role in the development of glucose sensors for home-use bypeople with diabetes. He published the first textbook on biosensorsin 1987 and is Editor-In-Chief of the principal journal in hisfield, Biosensors & Bioelectronics, which he co-foundedin 1985.
Table of Contents
Preface xvPart 1: New Materials and Methods 11 ZnO and Graphene Microelectrode Applications in Biosensing3Susana Campuzano, María Pedrero, Georgia-ParaskeviNikoleli, José M. Pingarron, Dimitrios P. Nikolelis, NikolaosTzamtzis and Vasillios N. Psychoyios1.1 Biosensors Based on Nanostructured Materials 41.2 Graphene Nanomaterials Used in ElectrochemicalBiosensorFabrication 51.3 ZnO Nanostructures Used in the Fabrication of ElectrochemicalBiosensors 71.4 Miniaturized Graphene and ZnO Nanostructured ElectrochemicalBiosensors for Food and Clinical Applications 101.5 Conclusions and Future Prospects 30Acknowledgements 32References 322 Assembly of Polymers/Metal Nanoparticles and TheirApplications as Medical Devices 37Magdalena Stevanovic2.1 Introduction 382.2 Platinum Nanoparticles 402.3 Gold Nanoparticles 412.4 Silver Nanoparticles 442.5 Assembly of Polymers/Silver Nanoparticles 452.6 Conclusion 51Acknowledgements 51References 523 Gold Nanoparticle-Based Electrochemical Biosensors for MedicalApplications 63Ülkü Anik3.1 Introduction 633.2 Gold Nanoparticles 643.3 Conclusion 76References 764 Impedimetric DNA Biosensors Based on Nanomaterials 81Manel del Valle and Alessandra Bonanni4.1 Introduction 824.2 Electrochemical Impedance Spectroscopy for Genosensing 854.3 Nanostructured Carbon Used in Impedimetric Genosensors 914.4 Nanostructured Gold Used in Impedimetric Genosensors 974.5 Quantum Dots for Impedimetric Genosensing 1004.6 Impedimetric Genosensors for Point-of-Care Diagnosis 1014.7 Conclusions (Past, Present and Future Perspectives) 102Acknowledgements 104References 1045 Graphene: Insights of its Application in ElectrochemicalBiosensors for Environmental Monitoring 111G.A. Álvarez-Romero, G. Alarcon-Angeles and A.Merkoçi5.1 Introduction 1125.2 Environmental Applications of Graphene-based Biosensors1175.3 Conclusions and Perspectives 133References 1346 Functional Nanomaterials for Multifarious Nanomedicine141Ravindra P. Singh, Jeong-Woo Choi, Ashutosh Tiwari andAvinash Chand Pandey6.1 Introduction 1426.2 Nanoparticle Coatings 1456.3 Cyclic Peptides 1476.4 Dendrimers 1496.5 Fullerenes/Carbon Nanotubes/Graphene 1566.6 Functional Drug Carriers 157
6.7 MRI Scanning Nanoparticles 1626.8 Nanoemulsions 1656.9 Nanofibers 1666.10 Nanoshells 1696.11 Quantum Dots 1716.12 Nanoimaging 1796.13 Inorganic Nanoparticles 1806.14 Conclusions 182Acknowledgement 183References 183Part 2: Principals and Prospective 1997 Computational Nanochemistry Study of the MolecularStructure, Spectra and Chemical Reactivity Properties of the BFPFGreen Fluorescent Protein Chromophore 201Daniel Glossman-Mitnik7.1 Introduction 2017.2 Theory and Computational Details 2027.3 Results and Discussion 2067.4 Conclusions 233Acknowledgements 234References 2348 Biosynthesis of etal Nanoparticles and Their Applications239Meryam Sardar, Abhijeet Mishra and Razi Ahmad8.1 Introduction 2408.2 Synthesis of Metal Nanoparticles 2418.3 Applications 2538.4 Conclusions 255Acknowledgement 256References 2579 Ionic Discotic Liquid Crystals: Recent Advances andApplications 267Santanu Kumar Pal and Sandeep Kumar9.1 Introduction 2689.2 Part I: Chromonic LCs 2719.3 Part II: Thermotropic Ionic Discotic Liquid Crystals 282Acknowledgement 309References 30910 Role of Advanced Materials as Nanosensors in Water Treatment315Sheenam Thatai, Parul Khurana and Dinesh Kumar10.1 Introduction 31510.2 Nanoparticles 31810.3 Different Fabrication Methods of Nanoparticles 31910.4 Core Material/Nanofillers 32110.5 Shell Material/Nanomatrix 32410.6 Core-Shell Material 32610.7 Properties of Metal Nanoparticles and Core-ShellNanocomposites 33010.8 Detection of Heavy Metals Using Smart Core-ShellNanocomposites 33310.9 Conclusions 337Acknowledgement 337References 338Part 3: Advanced Structures and Properties 34511 Application of Bioconjugated Nanoporous Gold Films inElectrochemical Biosensors 347Leila Kashefi-Kheyrabadi, Abolhassan Noori and MasoudAyatollahi Mehrgardi11.1 Introduction 34811.2 Fabrication of Nanoporous Gold 34911.3 Nucleic Acids (NAs)-Based Biosensors 35111.4 Protein-Nanostructured Gold Bioconjugates in Biosensing35611.5 Conclusion 369References 36912 Combination of Molecular Imprinting and Nanotechnology:Beginning of a New Horizon 375Rashmi Madhuri, Ekta Roy, Kritika Gupta and Prashant K.Sharma12.1 Introduction 37612.2 Classification of Imprinted Nanomaterials 38312.3 Imprinted Materials at Nanoscale 42112.4 Conclusions and Future Outlook 427Acknowledgements 428References 42813 Structural, Electrical and Magnetic Properties of Pure andSubstituted BiFeO3 Multiferroics 433S. Jangid, S. K. Barbar and M. Roy13.1 Introduction 43413.2 Synthesis of Materials 44613.3 Structural and Morphological Analyses 45413.4 Electrical Properties 46713.5 Magnetic Properties 47613.6 Thermal Analysis (MDSC Studies) 48913.7 Summary and Conclusion 496References 49814 Synthesis, Characterization and Rietveld Studies ofSr-modified PZT Ceramics 507Kumar Brajesh, A.K. Himanshu and N.K. Singh14.1 Introduction 50814.2 Experiment 50914.3 Rietveld Refinement Details 51014.4 Results and Discussion 51114.5 Conclusions 521References 521Index 523