Under the broad heading of blood oxygenation there may be specific areas of study, such as the kinetics of the oxygen hemoglobin reaction, diffusion of gases through the red cell, blood preservation, blood chemistry, oxygen electrode design and the design and evaluation of artificial blood oxygenators. ~lood oxygenation is of interest to many disciplines including physicians, chemists, physicists, biologists, physiologists and engineers. The International Symposium on Blood Oxygenation was or ganized in order to bring together the people working in the various areas of blood oxygenation. This multidiscipline meet ing was held at the University of Cincinnati on December 1, 2 and 3 of 1969. It was jOintly sponsored by the U. S. Army Medi cal Research and Development Command and the University of Cin cinnati. Participants came from Australia, England, Israel, Italy, Japan and the United States. There were 122 persons registered for the Symposium. From the nature of the discussion during the meeting, it seemed apparent that the participants were benefiting from the contacts with colleagues in other disciplines. The result was a significant contribution to the present fund of knowledge of blood oxygenation and an enhancement of the future work.
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Table of ContentsFactors Determining the Velocity of Gas Uptake by Intracellular Hemoglobin.- Oxygenation Velocity of the Red Cell and Pulmonary Diffusing Capacity.- Membrane Resistance and Diffusion Coefficients: The Intact Red Cell.- Models for Simultaneous Diffusion and Chemical Reaction of Oxygen Within the Intact Red Cell of Whole Blood.- In Vitro Measurement of Uncombined Oxygen Concentration in Intact Red Cells.- The Interaction of Carbon Dioxide with the Rate of Exchange of Oxygen by Red Blood Cells.- Physicochemical Properties of Blood Constituents Derived from Porphyrins.- Equilibrium and Kinetic Aspects of the Reaction of Hemoglobin, Isolated Chains and Intermediates with Oxygen.- A Mathematical Analysis Predicting Cerebral Tissue Reoxygenation Time as a Function of the Rate of Change of Effective Cerebral Blood Flow.- Brain Tissue Oxygenation as Determined with a New Ultramicro Oxygen Electrode.- A Distributed Parameter Mathematical Analysis of Oxygen Exchange from Maternal to Fetal Blood in the Human Placenta.- The Effects of Inert Gases, Preservatives and Storage on Oxygen Transport in Blood.- The Control of Hemoglobin Function in Blood Stored for Transfusion Purposes.- Effect of Plasma Constituents on Oxygen Diffusivity.- Internal Viscosity of the Red Blood Cell and the Capillary Inversion Phenomena as Factors in Oxygen Transport.- The Oxygenation of Blood in Artificial Membrane Devices.- Design Considerations and Long-Term in Vivo Studies with the Disposable Spiral Membrane Lung.- A Mathematical Model for the Prediction of Oxygen, Carbon Dioxide, and pH Profiles with Augmented Diffusion in Capillary Blood Oxygenators.- Development of Capillary Membrane Blood Oxygenators.- Oxygenation of Blood for Clinical Applications.