This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the physiological components of malignant tumors. Among a range of topics, detailed consideration is given to circulatory parameters, including blood and nutrient supply, transvascular and interstitial transport, and oxygenation, as well as to bioenergetic status and the influence of pH on the responsiveness of malignant tumors to nonsurgical treatments such as radiotherapy and chemotherapy. For the clinician, it will be of special interest to read about the various invasive and noninvasive methods (including MR and PET) that allow the tumor physiology and microenvironment of an individual patient to be characterized.
Table of ContentsIntroduction; Morphological Aspects of Tumor Angiogenesis and Microcirculation; The Role of Microcirculation in the Treatment of Malignant Tumors: Facts and Fiction; Tumor Blood Flow; Clinical Investigations on Blood Perfusion in Human Tumors; Oxygenation of Human Tumors; The Prognostic Significance of Hypoxia in Cervical Cancer: A Radiobiological or Tumorbiological Phenomenon?; Changes in Tumor Oxygenation During Radiation Therapy; Misonidazole Labelling as a Marker of Cellular Hypoxia; Significance of Hemoglobin Concentration for Treatment Outcome; Tumor pH; Energy Status of Malignant Tumors in Patients and Experimental Animals; Therapeutic Significance of Microenvironmental Factors; Application of MR and PET for Investigation of Tumor Microenvironment; Modification of Blood Flow; Modification of Oxygen Supply; The Potential Benefit of Hypoxix Cytotoxins in Radio-Oncology; Subject Index; List of Contributors.