Bone Mineral Metabolism in Cancer

Bone Mineral Metabolism in Cancer

by J. Szymendera

Paperback(Softcover reprint of the original 1st ed. 1970)

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Product Details

ISBN-13: 9783642999802
Publisher: Springer Berlin Heidelberg
Publication date: 02/20/2012
Series: Recent Results in Cancer Research , #27
Edition description: Softcover reprint of the original 1st ed. 1970
Pages: 112
Product dimensions: 6.69(w) x 9.61(h) x 0.01(d)

Table of Contents

1 General Outlines of Bone Tissue Metabolism.- 1. Structure and Function of Bone Cells.- 2. Structure and Function of Bone Matrix.- 2.1. Collagen.- Composition and Structure of Collagen.- Collagen Synthesis and Maturation.- Catabolism of Collagen.- Excretion of Hydroxy-proline.- 2.2. Ground Substance.- Composition and Structure of Ground Substance.- Synthesis of Proteoglycans and Glycoproteins.- Catabolism of Proteoglycans and Glycoproteins.- 3. Bone Mineral.- Chemistry and Structure of Bone Mineral.- Amorphous/Crystalline Mineral Composition.- Properties of Bone Mineral.- Mineralization of Bone.- Regulation of Mineralization.- Resorption of Bone Mineral.- 2 General Outlines of a Clinical Approach to Bone Tissue Metabolism.- 1. Calcium Metabolism.- Calcium Absorption.- Calcium in Body Fluids.- Renal Handling of Calcium.- Bone Calcium Accretion and Resorption.- Application of Tracer Kinetics to Calcium Metabolism.- Skeletal Hormones and Calcium Metabolism.- 2. Inorganic Phosphate Metabolism.- Phosphate in Body Fluids.- Renal Handling of Phosphate.- Application of Tracer Kinetics to Phosphate Metabolism.- Skeletal Hormones and Phosphate Metabolism.- 3. Collagen Metabolism and Urinary Hydroxyproline.- 4. Pyrophosphate Metabolism and Urinary Pyrophosphate.- 3 Methods of Studying Bone Mineral Metabolism.- 1. Plasma State and Renal Handling of Calcium and Phosphate.- General Design of Study.- Preparation and Ultrafiltration of Plasma.- Preparation of Urine.- Calculation of Diffusible Calcium and Phosphate.- Calculation of Renal Handling of Calcium and Phosphate.- 2. Kinetics of Calcium Metabolism.- General Design of Study.- Tracers.- Kinetic Study.- Preparation of Samples for Analysis and Radioactivity Determinations.- Preliminary Presentation of Data.- 3. Kinetics of Inorganic Phosphate Metabolism.- General Design of Study.- Tracer.- Kinetic Study.- Preparation of Samples for Analysis and Radioactivity Determination.- Preliminary Presentation of Data.- 4. Multicompartmental Analysis of Calcium and Phosphate Kinetics.- 5. Urinary Pyrophosphate.- 6. Other Methods.- 4 The Metabolism of Bone Mineral in Malignancy without Evidence of Bone Destruction.- 1. Metabolism of Calcium and Inorganic Phosphate.- 1.1. Clinical Material.- 1.2. Results.- Plasma State of Calcium and Inorganic Phosphate.- Renal Handling of Calcium and Inorganic Phosphate.- Calcium Kinetics.- Inorganic Phosphate Kinetics.- 2. Effects of Castration on Plasma State and Renal Handling of Calcium and Inorganic Phosphate.- 2.1. Clinical Material.- 2.2. Results.- Plasma Data.- Urinary Data.- 3. Discussion.- 3.1. Plasma State of Calcium and Inorganic Phosphate.- 3.2. Renal Handling of Calcium and Inorganic Phosphate.- Effects of Castration on Bone Mineral Metabolism.- 3.3. Calcium Kinetics.- 3.4. Phosphate Kinetics.- 5 The Metabolism of Bone Mineral in Malignancy with Bone Lesions.- 1. Patients with Plasmacytoma.- 1.1. Clinical Material.- 1.2. Results.- Plasma State of Calcium and Inorganic Phosphate.- Renal Handling of Calcium and Inorganic Phosphate.- Calcium Kinetics.- Inorganic Phosphate Kinetics.- 2. Patients with Cancer of the Breast.- 2.1. Clinical Material.- 2.2. Results.- Plasma State and Renal Handling of Calcium and Inorganic Phosphate.- Calcium Kinetics.- Oophorectomized Patients.- Postmenopausal Patients.- Inorganic Phosphate Kinetics.- 3. Discussion.- 3.1. Patients with Plasmacytoma.- 3.2. Patients with Cancer of the Breast.- General Summary.- Notations.- Analysis.- References.

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