A comprehensive state-of-the-art summary of breast cancer research and treatment by leading authorities. The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis. In addition, the authors describe current and future methods of breast cancer treatment in depth, and discuss environment and diet as risk factors for the disease. Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics constitutes an excellent reference and resource for all those clinical and experimental oncologists, as well as genetic counselors nurses, who need to understand the latest developments in breast cancer biology, risk, and treatment.
Table of ContentsPart I. Etiology: Genetic Changes Associated with Breast Cancer. The Estrogen Receptor and Breast Cancer, R. K. Hansen and S. A. W. Fuqua. Epidermal Growth Factor-Related Peptides and Their Cognate Receptors in Breast Cancer, Isabel Martinez-Lacaci, Caterina Bianco, Marta De Santis, and David S. Salomon. The Role of Fibroblast Growth Factors in Breast Cancer Pathogenesis and Progression, Francis G. Kern. Transforming Growth Factor-ß and Breast Cancer, Katri M. Koli and Carlos L. Arteaga. The Insulin-Like Growth Factor Network and Breast Cancer, Matthew J. Ellis. Molecular Alterations in Breast Cancer, Ivan Bergstein. Apoptosis and the Development of Breast Cancer, Priscilla A. Furth. WNT Genes and Breast Cancer, Ivan Bergstein and Anthony M. C. Brown. Hereditary Breast Cancer Genes, Lynda B. Bennett, Joel D. Taurog, and Anne M. Bowcock. Biological Functions of the BRCA1 and BRCA2 Proteins, Helen K. Chew, Andrew A. Farmer, and Wen-Hwa Lee. Psychosocial Issues in BRCA1/2 Testing, Caryn Lerman and Beth N. Peshkin. Part II. Biology of Tumor Progression: Breast Cancer Metastasis. Nm23, Breast Differentiation, and Cancer Metastasis, Patricia S. Steeg, Melanie T. Hartsough, and Susan e. Clare. Role of Integrins in the Development and Malignancy of the Breast, Edward C. Rosfjord and Robert B. Dickson. Matrix Metalloproteinases in the Pathogenesis of Breast Cancer, John R. MacDougall and Lynn M. Matrisian. The Urokinase Plasminogen Activation System in Breast Cancer, Anders N. Pedersen, Claus Holst-Hansen, Thomas L. Frandsen, Boye Schnack Nielsen, Ross W. Stephens, and Nils Brünner. Angiogenesis in Breast Cancer: Role in Biology, Tumor Progression, and Prognosis, Giampietro Gasparini. Part III. Therapeutics and Diagnostics: Diagnosis. Cytogenetic Approaches to Breast Cancer, Sverre Heim, Manuel R. Teixeira, and Nikos Pandis. Current and Future Directions in Surgical and Chemotherapeutic Approaches to Breast Cancer Treatment, George N. Peters. Breast Cancer Therapy UsingMonoclonal Antibodies Against Epidermal Growth Factor Receptor and HER-2, Zhen Fan and John Mendelsohn. Towards the Therapeutic Targeting of Matrix Metalloproteinases in Breast Cancer, Erik W. Thompson and George W. Sledge, Jr. MUC1 Mucin as a Tumor Antigen in Breast Cancer, Pawel Ciborowski, Elisabeth M. Hiltbold, Simon M. Barratt-Boyes, and Olivera J. Finn. Aromatase Inhibitors and the Role of Hormonal Therapy in Breast Cancer, Kendall E. Donaldson Herschler and Angela Brodie. Drug Resistance in Breast Cancer, Devchand Paul and Kenneth H. Cowan. Smoking as a Risk Factor for Breast Cancer, Christine B. Ambrosone and Peter G. Shields. The Estrogenicity of Selected Nutrients, Phytochemicals, Pesticides, and Pollutants: Their Potential Roles in Breast Cancer, Leena Hilakivi-Clarke, Bruce Trock, and Robert Clarke. Index.