Cancer and the Heart

by Michael S. Ewer MD, MPH, JD, LLM, MBA, PhD (Editor)

Overview

In Cancer and the Heart, third edition, Dr. Ewer and colleagues at MD Anderson are joined by national and international authorities who contributed to the 28 chapters of this volume. The various authors present their insights into the effects of anticancer drugs and radiation treatment on the heart, and other organ systems. Discussions are advanced on imaging strategies and techniques with an emphasis on specific clinical problems experienced by physicians and their patients. Readers will find a useful reference intended to help them recognize the decision-making dilemmas they face providing optimal tumor management, and a useful resource to help them and their cancer patients cope with inevitable challenges.

Product Details

ISBN-13:	9781607959649
Publisher:	PMPH USA, Ltd.
Publication date:	11/20/2019
Sold by:	Barnes & Noble
Format:	eBook
Pages:	634
File size:	25 MB
Note:	This product may take a few minutes to download.

About the Author

Michael S. Ewer, MD, MPH, JD, LLM, MBA, PhD, is an Internist and Professor at the University of Texas MD Anderson Cancer Center in Houston, Texas. He is also Special Assistant to the Chief Quality Officer at MD Anderson. Dr. Ewer has authored more than 300 chapters, articles, and abstracts and is the editor of the three editions of Cancer and the Heart, the first two editions with co-editor Edward T.H. Yeh, MD.

Table of Contents

Chapter 1. Principles of Oncologic Chemotherapy and Immunotherapy by Louis E. Fayad, Alison Woo, and Larry W.Kwak Chapter 2. Pharmacology of Cardio-Oncology by Emanuela Salvatorelli, Pierantonio Menna, Giorgio Minotti Chapter 3. Anthracycline Cardiotoxicity: Clinical Aspects, Recognition, Monitoring, Treatment, and Prevention by Michael S. Ewer Chapter 4. Trastuzumab-Associated Cardiotoxicity by Thomas M. Suter and Michael S. Ewer Chapter 5. Mechanisms of Anti-HER2 Cardiotoxicity: Interference with Neuregulin-1 Cardioprotective Signaling by Zarha Vermeulen, Vincent Segers, and Gilles W. De Keulenaer Chapter 6. Checkpoint Inhibitors by Lavanya Kondapalli, Rupal O’Quinn, and Joseph R. Carver Chapter 7. Effects of Radiation Therapy on the Cardiovascular System by David J. Cutter, Carolyn W. Taylor, Kazem Rahimi, Paul McGale, Vanessa Ferriera, Matthew Burrage, Sindu Vivekanandan, Maria Hawkins, and Sarah C. Darby Chapter 8. Cardiac Amyloidosis by Syed Wamique Yusuf Chapter 9. Cardiac Arrhythmias in the Cancer Patient by Asif Jafferani, Syed Wamique Yusuf, and Steven M. Ewer Chapter 10. Cardiac Ultrasonography, Doppler Imaging, and Related Techniques for Cancer Patients by Jose Banchs and Thomas H. Marwick Chapter 11. Diagnosis of Cardiac Tumors by Ali Agha, Purvi Parwani, and Juan C. Lopez-Mattei Chapter 12. Pericardial Disease in the Cancer Patient by Steven M. Ewer Chapter 13. Arterial and Venous Thromboembolic Disease in Cancer Patients by Elie Mouhayar Chapter 14. Cardiac Tumors by Daniel Perry, Monika Leja, Scott Schuetze, Shanda H. Blackmon, and Michael J. Reardon Chapter 15. Carcinoid Heart Disease by Saamir A. Hassan Chapter 16. Cardiac Monitoring During Clinical Trials by Nicolas Palaskas and Michael S. Ewer Chapter 17. Cardiovascular Toxicity of Antiangiogenic Therapy: Mechanisms and Management by Divyanshu Mohananey, Rohit Kumar, and Tochi M. Okwuosa Chapter 18. Heart–Lung Interactions in the Cancer Patient by Vickie R. Shannon and Saadia A. Faiz Chapter 19. Cardiac Emergencies Among Cancer Patients by Carmen P. Escalante and Sai-Ching Jim Yeung Chapter 20. Cardiac Considerations for Treating Cancer in Infants and Children by Neha Bansal, Rofida Nofal, Sanjeev Aggarwal, Vivian I. Franco, Emma R. Lipshultz, Stephen E. Sallan, and Steven E. Lipshultz Chapter 21. Infectious Endocarditis in Cancer Patients by Eduardo Yepez Guevara, Jose Banchs, David J. Tweardy, and Javier Adachi Chapter 22. Magnetic Resonance Imaging and Therapeutic Radiation in Cancer Patients with Implanted Pacemaker or Defibrillator Devices by Kaveh Karimzad Chapter 23. Cardiovascular Interventions for Cancer Patients by Ezequiel Muñoz, Brian Greet, Konstantinos Marmagkiolis, and Cezar Iliescu Chapter 24. Psychosocial Considerations in Treating the Cancer Patient with Heart Disease by Anecita P. Fadol Chapter 25. Preoperative Assessment of the Cancer Patient for Noncardiovascular Surgery by Marc A. Rozner, Shital Vachhani, Teresa Moon, and January Y. Tsai Chapter 26. Advanced Heart Failure in Patients with Cancer by Sadeer G. Al-Kindi and Guilherme H. Oliveira Chapter 27. Pregnancy and the Heart in Cancer Patients and Survivors by Kara A. Thompson Chapter 28. Exercise in the Cancer Patient: Cardiac Considerations by Susan C. Gilchrist Index

Preface

Over the last 60 years, the field of cardio-oncology has evolved significantly. Oncologists have long been concerned about cardiac reserves for surgical candidates, the effects of radiation on the heart, and how patients with underlying cardiac conditions might fare when treated for cancer. It wasn't until the discovery that anthracyclines cause heart failure, however, that integrating cardiac evaluations and testing became a part of the oncologic practice. The University of Texas MD Anderson Cancer Center was among the first cancer hospitals to introduce techniques like cardiac ultrasound along with the now, nearly forgotten, parameters of systolic time intervals, apex-cardiography, and vector electrocardiography.MD Anderson was the first cancer center to have a vigorous heart biopsy program, initially implemented to manage patients receiving anthracyclines, but presently optimized to expand patient care and research involving newer classes of anticancer agents. Our institution also has the first cancer treatment-related cardiac catheterization laboratory. In December 2017, when I became MD Anderson’s fifth president and reflected on the institution’s contributions to this field, one of my desires for advancements in years to come was to broaden therapeutic options for patients with cancer, including patients with underlying cardiac conditions. As we continue to advance research and harness genomic and immunologic tools, several new cancer treatment strategies could raise concerns of cardiac dysfunction. Such concerns include those related to new imaging techniques; updated understanding of how cancer drugs affect cardiac structure and function; modern initiatives of cardiac protection for both chemotherapy and radiation therapy patients; and cardiac complications related to checkpoint inhibitors. It is in this context that various authors, from MD Anderson as well as other internationally recognized authorities, present the third edition of Cancer and the Heart. I hope that you find this material stimulating, interesting and, most importantly, useful. Our collective hope is that the material herein will ultimately serve to help cancer patients in Texas, across the nation and all over the world better tolerate the burdens of their treatment. For those further along in their cancer journey, we hope that this knowledge will help these survivors lead lives more fully, without experiencing potentially avoidable cardiac complications. This work advances us further down the road to our ultimate goal—to end cancer, once and for all.