Cancer Chemotherapy and Biotherapy: Principles and Practice

Cancer Chemotherapy and Biotherapy: Principles and Practice

by Bruce A. Chabner, Dan L. Longo

NOOK Book(eBook)

$259.99
View All Available Formats & Editions

Available on Compatible NOOK Devices and the free NOOK Apps.
WANT A NOOK?  Explore Now

Product Details

ISBN-13: 9781451148206
Publisher: Wolters Kluwer Health
Publication date: 12/07/2011
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 848
File size: 15 MB
Note: This product may take a few minutes to download.

Read an Excerpt

The skilled physicians treating patients with cancer have a daunting task in that they need to understand pharmacology, pharmacokinetics, pharmacogenetics, pharmacodynamics, drug metabolism, drug resistance, cancer cell biology, normal cell biology, and myriad drug interactions, in addition to considerations of alterations in physiology caused by the cancer or associated with concurrent disease or advanced age that influence these distinct facets that in turn influence drug action. In this book, we have attempted to incorporate relevant information that will assist the caregiver in planning the optimal treatment approach for each individual patient. It is our intention to keep the information in this text up to date through the addition of relevant information on newly approved drugs to the new online version of this book that appears at http://www.lwwoncology.com. We look forward to your feedback about how to make this book more useful to you.
—Bruce A. Chabner, M.D.,Dan L. Longo, M.D.

Table of Contents

Contributing Authorsvii
Prefacexi
Acknowledgmentsxii
1.Clinical Strategies for Cancer Treatment: The Role of Drugs1
2.Preclinical Aspects of Cancer Drug Discovery and Development17
3.Pharmacokinetics and Clinical Monitoring37
4.Infertility after Cancer Chemotherapy50
5.Carcinogenesis: A Late Complication of Cancer Chemotherapy67
6.Steroid Hormone Therapies for Cancer85
7.Antifolates139
8.5-Fluoropyrimidines185
9.Cytidine Analogs265
10.Purine Antimetabolites295
11.Hydroxyurea315
12.Antimicrotubule Agents329
13.Alkylating Agents373
14.Nonclassic Alkylating Agents415
15.Cisplatin and Analogs447
16.Bleomycin466
17.Antitumor Antibiotics482
18.Anthracyclines and Anthracenediones500
19.Topoisomerase II Inhibitors: Epipodophyllotoxins, Acridines, Ellipticines, and Bisdioxopiperazines538
20.Topoisomerase I Targeting Agents: The Camptothecins579
21.Enzyme Therapy: L-Asparaginase647
22.Pharmacologic Considerations in Chemotherapy for Brain Tumors657
23.Retinoids and Other Differentiating Agents678
24.Bisphosphonates700
25.Radiation Modifiers707
26.Pharmacology of Interferons: Induced Proteins, Cell Activation, and Antitumor Activity752
27.Clinical Pharmacokinetics of Interleukin 1, Interleukin 2, Interleukin 4, Tumor Necrosis Factor, Interleukin 12, and Macrophage Colony-Stimulating Factor779
28.Colony-Stimulating Factors829
29.Antibody-Based Immunotherapies for Cancer850
30.Targeted Therapy891
31.Physical Barriers to Drug Delivery911
32.Adoptive Cellular Therapy925
33.Cancer Vaccines 2001951
34.Cytokine and Growth Factor and Receptor Database: Biologic, Molecular, and Pathophysiologic Properties of Ligand-Receptor Interactions960
35.Inhibitors of Tumor Angiogenesis988
36.Pharmacogenetics998
37.Chemokine--Chemokine Receptor Database 2001: Biologic, Molecular, and Pathophysiologic Properties of Chemokine-Receptor Interactions1012
Index1129

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews