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Cold Spring Harbor Laboratory Press


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Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression.

The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

Product Details

ISBN-13: 9781621821434
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 09/30/2017
Series: Perspectives CSHL Series
Pages: 304
Product dimensions: 10.20(w) x 7.30(h) x 0.90(d)

Table of Contents


1. Evolution of Premalignant Disease
Kit Curtius, Nicholas A. Wright, and Trevor A. Graham

2. Cancer Stem Cells and Clonal Evolution
Tariq Enver

3. Spatial Heterogeneity in the Tumor Microenvironment
Yinyin Yuan

4. Tumor Microenvironment and Differential Responses to Therapy
Eishu Hirata and Erik Sahai

5. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity
John D. Martin, Dai Fukumura, Dan G. Duda, Yves Boucher, and Rakesh K. Jain

6. Therapy-Induced Cancer Evolution
Barry Taylor and Joseph Costello

7. Co-Evolution of Leukemia and Host Immune Cells in Chronic Lymphocytic Leukemia (CLL)
Noelia Purroy and Catherine J. Wu

8. Tumor Heterogeneity-The Achilles Heel for Cancer Immunotherapy
Sergio Quezada and Karl Peggs

9. Cancer Drug Resistance in Light of Clonal Evolution: Novel Trial Designs
Robert A. Gatenby

10. Order Matters: The Order of Somatic Mutations Influences Cancer Evolution
David G. Kent and Anthony R. Green

11. The Role of Aneuploidy in Cancer Evolution
Laurent Sansregret and Charles Swanton

12. Principles of Reconstructing the Subclonal Architecture of Cancers
Stefan C. Dentro, David C. Wedge, and Peter Van Loo

13. The Cellular Origin and Evolution of Breast Cancer
Mei Zhang, Adrian V. Lee, and Jeffrey M. Rosen

14. Phylogenetic Quantification of Intra-Tumour Heterogeneity
Thomas B.K. Watkins and Roland F. Schwarz

15. Simulating Cancer Evolution Through Space and Time
Alexander Anderson

16. Big Bang Models of Tumor Evolution
Christina Curtis

17. Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies
Mariangela Russo and Alberto Bardelli

18. Studies of Clonal Evolution Simulations in Animals Models
Sohrab Shah

19. Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution
Samuel F. Bakhoum and Dan Avi Landau

20. Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks
Angelo Fortunato, Amy Broddy, Diego Mallo, Athena Aktipis, Carlo C. Maley, and John W. Pepper


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