Cancer Prevention: Novel Nutrient and Pharmaceutical Developments

Cancer Prevention: Novel Nutrient and Pharmaceutical Developments

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Cancer Prevention: Novel Nutrient and Pharmaceutical Developments by H. Leon Bradlow

In this book a group of leading authorities examines several classes o f nutrients and pharmaceutical agents currently believed to be importa nt for tumor inhibition. The authors review novel preclinical models t hat facilitate analyzing chemopreventive agencts' efficacy and mechani sms of gene-nutrient interaction. They also provide current informatio n on recent clinical trials underway studying chemopreventive regimens in the United States, Europe, and Asia.

Product Details

ISBN-13: 9780801865442
Publisher: New York Academy of Sciences
Publication date: 06/16/2000
Series: Annals of the New York Academy of Sciences Ser.
Edition description: New Edition
Pages: 264
Product dimensions: 5.98(w) x 8.96(h) x 0.59(d)

About the Author

H. L. Bradlow, Jack Fishman, and Michael P. Osborne are with the Strang Cancer Prevention Center at Rockefeller University.

Table of Contents

Progress in Cancer Chemoprevention1
Part I.Application of Preclinical Genetic Models to Cancer Prevention Studies
Preclinical Mouse Models for Cancer Chemoprevention Studies14
Cellular Mechanisms of Risk and Transformation20
APC and Intestinal Carcinogenesis: Insights from Animal Models32
Oncogenic Activating Mutations in the neu/erbB-2 Oncogene Are Involved in the Induction of Mammary Tumors45
Part II.Cyclooxygenase-2 and Cancer Prevention
Cyclooxygenase-deficient Mice: A Summary of Their Characteristics and Susceptibilities to Inflammation and Carcinogenesis52
Inhibition of Cyclooxygenase-2 Expression: An Approach to Preventing Head and Neck Cancer
The Role of COX-2 in Intestinal Cancer72
COX-2 Inhibitors: A New Class of Antiangiogenic Agents84
Micronutrient Deficiencies: A Major Cause of DNA Damage87
Part III.Calcium and Vitamin D in Cancer Prevention
Calcium and Vitamin D: Their Potential Roles in Colon and Breast Cancer Prevention107
Preclinical and Early Human Studies of Calcium and Colon Cancer Prevention120
Studies of Calcium in Food Supplements in Humans128
Calcium Supplements and Colorectal Adenomas138
Part IV.Cancer Prevention Updates
Breast Cancer Prevention by Antiestrogens146
European Trials on Dietary Supplementation for Cancer Prevention152
Update from Asia: Asian Studies on Cancer Chemoprevention157
Squalene, Olive Oil, and Cancer Risk: Review and Hypothesis193
Multifunctional Aspects of the Action of Indole-3-Carbinol as an Antitumor Agent204
Resveratrol Inhibits Cyclooxygenase-2 Transcription in Human Mammary Epithelial Cells214
Part V.Poster Papers
Modification of Dietary Habits (Mediterranean Diet) and Cancer Mortality in a Southern Italian Village from 1960 to 1996224
Season-specific Correlation between Dietary Intake of Fruits and Vegetables and Levels of Serum Biomarkers among Chinese Tin Miners at High Risk for Lung Cancer230
BRCA 1/2 Gene Mutation Testing-based Cancer Prevention and the Moral Concerns of Different Types of Patients240
Cohort Analysis of Etiolgical Factors for Colorectal Cancer following Endoscopic Resection of Colorectal Tumors244
Negative Growth Regulation of Oncogene-transformed Human Breast Epithelial Cells by Phytochemicals: Role of Apoptosis247
Fecal pH from Patients with Colorectal Tumors253
Oncogenetic Information in the Hands of Physicians and the Preventive Options of Persons Who Are Not Their Patients256
Index of Contributors263

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