Pub. Date:
Springer US
Cannabinoids / Edition 1

Cannabinoids / Edition 1

by Vincenzo Di Marzo
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The 21st century will witness the unprecedented marketing of therapeutic drugs developed from cannabinoids and the endocannabinoid system. Cannabinoids is a timely volume, which represents a comprehensive review of the most important issues in cannabinoid research as well as those of most likely therapeutic relevance. For the first time, the multi-faceted aspects of cannabinoid chemistry, biology and medicine are presented in one volume.
Key topics of discussion:

-major families of phytocannabinoids;
-pharmacological activity of phytocannabinoids;
-interactions of phytocannabinoids with their proposed molecular target;
-components of the endocannabinoid system;
-molecular mechanisms of the endocannabinoid system;
-Physiological and pathological role of endocannabinoids;
-industrial applications of studies on the cannabinoids;
-therapeutic uses of agonists and antagonists of cannabinoids receptors.

This book is a must for graduate and pre- and post-doctoral students in disciplines ranging from organic and natural product chemistry, pharmacology, biochemistry and medicine.

Product Details

ISBN-13: 9781441934338
Publisher: Springer US
Publication date: 10/09/2011
Series: Neuroscience Intelligence Unit
Edition description: 2004
Pages: 216
Product dimensions: 6.00(w) x 9.00(h) x 0.60(d)

About the Author

Vincenzo Di Marzo is considered as one of the foremost authorities in cannabinoid research. He is a Research Director at the Institute of Biomolecular Chemistry of the National Research Council (ICB-CNR), Naples, Italy; coordinator of the Endocannabinoid Research Group in the Naples region; and an Adjunct Associate Professor in the Department of Pharmacology and Toxicology at the Medical College of Virginia at Virginia Commonwealth University in Richmond.

Table of Contents

1.The Chemical Constituents of Cannabis sativa and the Endocannabinoid System1
2.Pharmacology and Medicinal Chemistry of THC8
Pharmacology of THC9
Medicinal Chemistry16
3.The Pharmacology and Therapeutic Potential of Cannabidiol32
Receptor Interactions of Cannabidiol35
Effects of CBD on Central and Peripheral Neurotransmission42
Fate of Anandamide and Palmitoylethanolamide43
Anxiolytic and Antipsychotic Effects44
Anticonvulsant Effects of CBD46
Neuroprotective Effect of CBD53
Effects of CBD on the Production of Mediators of Inflammation and Immune Responses54
Effects of CBD on Cancer Cell Proliferation59
Effects of CBD on Cytochrome P450 (CYP) Isozymes60
Effects of CBD on Membrane Fluidity and Stability61
Other Effects of CBD62
Interactions between CBD and [Delta superscript 9]-THC64
Structure-Activity Relationships65
4.Cannabinoid Receptors and Signal Transduction84
CB[subscript 1] Receptor and Signal Transduction Pathways84
CB[subscript 2] Receptor and Signal Transduction Pathways87
Endothelial Anandamide Receptor: Pharmacology and Signal Transduction Pathways88
Mechanism of Receptor-Mediated G Protein Coupling88
Discovery of the Endocannabinoids99
Quantitative Analysis of Endocannabinoids in Mammals100
Biosynthesis, Action and Inactivation of Endocannabinoids101
Possible Physiological and Pathological Functions of Endocannabinoids in the CNS--An Overview113
Endocannabinoids: Relax, Eat, Rest, Forget and Protect118
6.Chemistry and Structure Activity Relationships for Tetrahydrocannabinols and Endocannabinoids131
Pyrazole Based Antagonists141
7.Cannabinoids and Medicine: Eating Disorders, Nausea and Emesis147
Endocannabinoids and the Physiological Regulation of Appetite and Body Weight147
Disorders of Appetite and Body Weight150
Cachexia, Anorexia and Malnutrition in Disease152
Nausea and Emesis155
8.Cannabinoids and Medicine II: The Role of Cannabinoids in Multiple Sclerosis and Neuronal Damage161
Multiple Sclerosis162
Head Injury and Stroke167
Parkinson's Disease170
Huntington's Disease171
Motor Neuron Diseases172
Alzheimer's Disease173
9.Endocannabinoids and Related Fatty Acid Derivatives in Pain Modulation: Behavioral, Neurophysiological and Neuroanatomical perspectives on Cannabinoid Antinociception181
Functional Significance of a Cannabinoid Transmitter System181
Subtypes of Cannabinoid Receptors182
Cannabinoid Receptor Pharmacology183
Antinociceptive Effects of Cannabinoids183
Cannabinoid-Induced Suppression of Nociceptive Transmission183
Spinal and Peripheral Cannabinoid Antinociceptive Mechanisms184
Evidence for Endocannabinoid Modulation of Nociception at the Supraspinal Level187
Role of Other Endocannabinoids and Related Fatty Acid Derivatives189
Localization of Cannabinoid Receptors and mRNA190
Cannabinoid Receptor Distribution on Central Terminals of Primary Afferents193
10.Endocannabinoids and Alcohol Drinking Behavior205
Endocannabinoids and Brain Reward Mechanisms205
Endocannabinoids As Regulators of Alcohol Preference206
Age-Dependence of Alcohol Preference and Endocannabinoid Signaling in Mice207
Endocannabinoids and Alcohol-Withdrawal209
A New Hypothesis209

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