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Carcinogenesis by P. Hohn

1. Concepts on the Causal Genesis of Human Intestinal Tumors The action of chemical substances has a significant role in the genesis of human tumors. It is assumed that most human tumors are induced by exogenous chemical noxae (Schmahl, 1970;Heidelberger, 1975; and others). In the course of intensive efforts to discover the principles of tumor etiology, important insights have resulted in recent years. These are that chemical carcinogens do not only arise as products of our tech­ nological civilization, but that they also occur in nature as potent solitary carcinogens and cocarcinogens (e. g. , as plant products). For review, see Hecker (1972) and Preuss­ mann (1975). Not only "complete" carcinogens are significant for the genesis of tu­ mors, but also substances which are first transformed to the actual carcinogenic com­ pound in the organism (Schmahl, 1975). The causal significance of exogenous noxae in carcinogenesis is indicated by the fact emphasized by Bauer (1963) that malignant tumors occur predilectively at those sites in the body which are in direct or indirect contact with the environment. This applies especially to the intestinal tract.

Product Details

ISBN-13: 9783642672941
Publisher: Springer Berlin Heidelberg
Publication date: 11/15/2011
Series: Current Topics in Pathology Series , #67
Edition description: Softcover reprint of the original 1st ed. 1979
Pages: 259
Product dimensions: 6.69(w) x 9.61(h) x 0.02(d)

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