Pub. Date:
Springer-Verlag New York, LLC
Cartilage and Osteoarthritis / Edition 1

Cartilage and Osteoarthritis / Edition 1


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An indispensable collection of updated classical and emerging techniques that promise to add critical knowledge to our understanding of cartilage metabolism in health and disease. Volume 1: Cellular and Molecular Tools describes proven molecular and cellular techniques for the in vitro study of normal and osteoarthritic cartilage through biochemical, biomolecular, immunological, and physical approaches, with emphasis on the genetic manipulation of cells. Volume 2: Structure and In Vivo Analysis, offers cutting-edge procedures for the study-at the tissue level-of turnover, structure, and functioning of normal and diseased articular cartilage by invasive and noninvasive means. Comprehensive and up-to-date, the two volumes of Cartilage and Osteoarthritis provide researchers and bench scientists with readily reproducible prools for new experiments to understand-from the cellular to the animal level-the pathophysiology of cartilage and to discover molecular targets for pharmacological intervention.

Product Details

ISBN-13: 9781588295057
Publisher: Springer-Verlag New York, LLC
Publication date: 08/04/2004
Series: Methods in Molecular Medicine , #101
Edition description: 2004
Pages: 346
Product dimensions: 5.98(w) x 9.02(h) x 0.03(d)

Table of Contents

Generation and Use of Transgenic Mice As Models of Osteoarthritis

Anna-Marja Säämänen and Eero Vuorio

Development and Clinical Application in Arthritis of a New Immunoassay for Serum Type IIA Procollagen NH2 Propeptide

Jean-Charles Rousseau, Linda J. Sandell, Pierre D. Delmas, and Patrick Garnero

Histological and Immunohistological Studies on Cartilage

James Melrose, Susan Smith, and Peter Ghosh

Hishemical Visualization of the Cartilage Hyaladherins Using a Biotinylated Hyaluronan Oligosaccharide Bioaffinity Probe

James Melrose and Susan Smith

Methods for Cartilage and Subchondral Bone Histomorphometry

Philippe Pastoureau and Agnès Chomel

Laser-Mediated Microdissection As a Tool for Molecular Analysis in Arthritis

Martin Judex, Elena Neumann, Steffen Gay, and Ulf Müller-Ladner

Analysis of Protein Distribution in Cartilage Using Immunofluorescence and Laser Confocal Scanning Microscopy

Stephan Soeder, Alexander Kuhlmann, and Thomas Aigner

Molecular and Biochemical Assays of Cartilage Components

Caroline D. Hoemann

Mechanical Characterization of Native and Tissue-Engineered Cartilage

Albert C. Chen, Stephen M. Klisch, Won C. Bae, Michele M. Temple, Kevin B. McGowan, Kenneth R. Gratz, Barbara L. Schumacher, and Robert L. Sah

Noninvasive Study of Human Cartilage Structure by MRI

Felix Eckstein

High-Resolution MRI Techniques for Studies in Small-Animal Models

Olivier Beuf

High-Resolution Imaging of Osteoarthritis Using Microcomputed Tomography

Lydia Wachsmuth and Klaus Engelke

High-Resolution Ultrasonography for Analysis of Age- and Disease-Related Cartilage Changes

Amena Saïed and Pascal Laugier

Evaluation of Cartilage Composition and Degradation by High-Resolution Magic-Angle Spinning Nuclear Magnetic Resonance

Jürgen Schiller, Daniel Huster, Beate Fuchs, Lama Naji, Jörn Kaufmann, and Klaus Arnold

Pulsed-Field Gradient-Nuclear Magnetic Resonance (PFG NMR) to Measure the Diffusion of Ions and Polymers in Cartilage: Applications in Joint Diseases

Jürgen Schiller, Lama Naji, Robert Trampel, Wilfred Ngwa, Robert Knauss, and Klaus Arnold

Dynamics of Collagen in Articular Cartilage Studied by Solid-State NMR Methods

Daniel Huster, Jürgen Schiller, and Klaus Arnold

Computerized Prool for Anatomical and Functional Studies of Joints

Sandra Martelli and Stefano Zaffagnini


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