Cell-Cell Junctions, Second Edition

Cell-Cell Junctions, Second Edition

Hardcover(2nd ed.)

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Neighboring cells are linked to each other by multimolecular complexes such as adherens junctions, desmosomes, and gap junctions. These complexes help maintain tissue integrity, act as barriers to permeability, reinforce cell polarity, and allow cells to communicate with each other.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of the organization, regulation, and dynamics of cell-cell junctions and the roles they play in morphogenesis, tissue homeostasis, and disease. The contributors examine the assembly and structure of different cell-cell adhesion systems, the plasticity of cell-cell junctions (e.g., during cell migration), and how the junctions act as hubs to sense and transduce various mechanical and chemical signals.

The authors also discuss the roles of cell-cell junctions in specific developmental and physiological processes, such as hearing, skeletal myogenesis, and neural circuit assembly, as well as in diseases such as cancer. This volume is therefore an indispensable reference for cell and developmental biologists, as well as anyone interested in understanding the roles of these complexes in human health and disease.

Product Details

ISBN-13: 9781621821519
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 11/30/2017
Series: Perspectives CSHL Series
Edition description: 2nd ed.
Pages: 384
Product dimensions: 10.20(w) x 7.30(h) x 1.00(d)

Table of Contents


Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions
René Marc Mège and Noboru Ishiyama

Signaling by Small GTPases at Cel-Cell Junctions: Protein Interactions Building Control and Networks
Vania Braga

Cell Junctions in Hippo Signaling
Ruchan Karaman and Georg Halder

Mechanosensing and Mechanotransduction at Cell-Cell Junctions
Alpha S. Yap, Kinga Duszyc, and Virgile Viasnoff

Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin
Lena Brüser and Sven Bogdan

Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics
Mechthild Hatzfeld, René Keil, and Thomas M. Magin

Making Connections: Guidance Cues and Receptors at Nonneural Cell-Cell Junctions
Ian V. Beamish, Lindsay Hinck, and Timothy E. Kennedy

Cell-Cell Junctions Organize Structural and Signaling Networks
Miguel A. Garcia, W. James Nelson, and Natalie Chavez

Tuning Collective Cell Migration by Cell-Cell Junction Regulation
Peter Friedl and Roberto Mayor

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective
Matthias Rübsam, Joshua A. Broussard, Sara A. Wickström, Oxana Nekrasova, Kathleen J. Green, and Carien M. Niessen

Cell-Cell Contact and Receptor Tyrosine Kinase Signaling
Christine Chiasson-MacKenzie and Andrea I. McClatchey

Hold Me, but Not Too Tight - Endothelial Cell-Cell Junctions in Angiogenesis
Anna Szymborska and Holger Gerhardt

Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance
Avinash Jaiganesh, Yoshie Narui, Raul Araya-Secchi, and Marcos Sotomayor

Keep Your Friends Close: Cell-Cell Contact and Skeletal Myogenesis
Robert S. Krauss, Giselle A. Joseph, and Aviva J. Goel

The Cadherin Superfamily in Neural Circuit Assembly
James D. Jontes

Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease
Aaron Buckley and Jerrold R. Turner

Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease
Maria Grazia Lampugnani, Elisabetta Dejana, and Costanza Giampietro

Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer
Heather C. Bruner and Patrick W.B. Derksen

Connexins and Disease
Mario Delmar, Dale W. Laird, Christian C. Naus, Morten S. Nielsen, Vytautas K. Verselis, and Thomas W. White


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