Cell Injury Mechanisms Response Repair / Edition 1 available in Paperback
- Pub. Date:
When cells are damaged, as often occurs during trauma and metabolicstress, a highly evolved cell healing process follows that wasdesigned to enhance cell survival or remove irreparably injuredcells. Following injury, cells attempt to seal breaks in theirmembranes, chaperone removal or refolding of altered proteins,repair damaged DNA, or if necessary commit to programmed celldeath.
When cell injury is too extensive to permit reparativeresponses, acute cellular necrosis or apoptosis can result.Understanding injury at the subcellular organelle and molecularlevels is essential for development of new therapeutic strategiesand for optimal management of injured victims.
In this volume, various modes of injury that can occur aredescribed, as well as the basic molecular healing responses andpathways of metabolic survival or death. The approach taken here isto look at these processes at the cellular and subcellular levels,rather than at the tissue level, and this volume will be a valuableresource to anyone interested in wound healing, biological stressresponses, molecular chaperones, radiobiology, biomechanics, andbiomedical engineering, as well as trauma and critical caremedicine.
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Table of Contents
Foreword: Thomas K. Hunt.
Introduction: Raphael C. Lee, Florin Despa, and Kimm J.Hamann.
Part I: Cell Structure and Integrity:.
1. Biological Water: Its Vital Role in Macromolecular Structureand Function: Florin Despa.
2. Thermal Stability of Proteins: John C. Bischof and XiaomingHe.
3. The Physics of the Interactions Governing Folding andAssociation of Proteins: Weihua Guo, Joan-Emma Shea, and R StephenBerry.
4. Molecular Crowding Effects on Protein Stability: FlorinDespa, Dennis P. Orgill, and Raphael C. Lee.
Part II: Modes of Cell Injury:.
5. Mechanical Cell Injury: Kenneth A. Barbee.
6. Cell Injury by Electric Forces: Raphael C. Lee.
7. Electroconformational Denaturation of Membrane Proteins: WeiChen.
8. Heat Injury to Cells in Perfused Systems: Dennis P. Orgill,Stacy A. Porter, and Helena O. Taylor.
9. Cryo-Injury and Biopreservation: Alex Fowler and MehmetToner.
10. Oxidative Reactive Species in Cell Injury: Mechanisms inDiabetes Mellitus and Therapeutic Approaches: Leonid E. Fridlyandand Louis H. Philipson.
Part III: Cellular Responses to Injury:.
11. The Mechanisms of Cell Membrane Repair: A Tutorial Guide toKey Experiments: Richard A. Steinhardt.
12. The Role of Ca2+ in Muscle Cell Damage: Hanne Gissel.
13. Protein Denaturation and Aggregation: Cellular Responses toDenatured and Aggregated Proteins: Stephen C. Meredith.
14. Thermally Induced Injury and Heat-Shock Protein Expressionin Cells and Tissues: Marissa Nichole Rylander, Yusheng Feng, JonBass, and Kenneth R. Diller.
15. Cellular Response to DNA Damage: Johnny Kao, Barry S.Rosenstein, Sheila Peters, Michael T. Milano, and Stephen J.Kron.
16. Autophagy: Ameeta Kelekar.
17. Magnetic Resonance Imaging of Changes in Muscle Tissuesafter Membrane Trauma: Hanne Gissel, Florin Despa, John Collins,Devkumar Mustafi, Katherine Rojahn, Greg Karczmar, and RaphaelLee.
Part IV: Therapeutics for Cell Injury:.
18. Na+-K+ Pump Stimulation Improves Contractility in DamagedMuscle Fibers: Torben Clausen.
19. Multimodal Strategies for Resuscitating Injured Cells:Jayant Agarwal, Alexandra Walsh, and Raphael C. Lee.
20. Membrane Sealing by Polymers: Stacey A. Maskarinec, GuohuiWu, and Ka Yee C. Lee.
21. A Surfactant Copolymer Facilitates Functional Recovery ofHeat-Denatured Lysozyme: Alexandra M. Walsh, Devkumar Mustafi,Marvin W. Makinen, and Raphael C. Lee.
Index of Contributors