Cerebral Ischemia: Molecular and Cellular Pathophysiology / Edition 1 available in Hardcover
- Pub. Date:
- Springer-Verlag New York, LLC
In Cerebral Ischemia: Molecular and Cellular Pathphysiology, Wolfgang Walz and a panel of leading authorities illuminate those cellular and molecular mechanisms brought into play during a stroke that lead to neuronal dysfunction. Such damaging factors as spreading depression waves and postischemic depolarization, cell swelling, calcium overload, and oxygen radicals leading to necrosis and apoptosis are described in detail. Also examined are the body's repair mechanisms involving altered gene expression that lead to trophic factor production and heat shock protein synthesis, as well as to astrogliosis and microgliosis. All factors are presented in relation to their therapeutic value and the possible treatment approaches that evolve from their interactions.
Cerebral Ischemia: Molecular and Cellular Pathophysiology offers clinicians, interested practitioners, and experimentalists alike a systematic evaluation of all the major biological systems that contribute to brain dysfunction after a vascular accident. Its unique focus on mechanisms and gene expression also provides fresh and powerful insights into the many novel therapeutic strategies and agents for stroke management emerging today.
Table of Contents
Part I. Overview. Mechanisms of Cerebral Ischemic Damage, Costantino Iadecola. Part II. Factors in the Brain Microenvironment. Spreading Depression Waves as Mediators of Secondary Injury and of Protective Mechanisms, Anna Irwin and Wolfgang Walz. Cell Swelling in Cerebral Ischemia, Harold K. Kimelberg. Calcium Overload, Paul Morley, Joseph S. Tauskela, and Antoine M. Hakim. Oxygen Radicals, Pak H. Chan. Mechanisms of Neuroprotective Cytokines: Pleiotrophic Effects of TNFa and TGFb on Brain Injury, Annadora J. Bruce-Keller and Mark P. Mattson. Part III. Cellular Changes. Reprogramming of Gene Expression After Ischemia,Thaddeus S. Nowak, Jr. and Marika Kiessling. Neurons: Necrotic vs Apoptotic Changes, Koji Abe. Reactive Astrogliosis in the Injured and Postischemic Brain, Ronald Jabs, Lane K. Bekar, and Wolfgang Walz. Activated and Phagocytic Microglia,Yoichi Kondo. Index.