ISBN-10:
3527297545
ISBN-13:
9783527297542
Pub. Date:
05/28/1999
Publisher:
Wiley
Chemical Creativity: Ideas from the Work of Woodward, Huckel, Meerwein, and Others / Edition 1

Chemical Creativity: Ideas from the Work of Woodward, Huckel, Meerwein, and Others / Edition 1

by Jerome A. Berson, Jerome A. Bearson

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Product Details

ISBN-13: 9783527297542
Publisher: Wiley
Publication date: 05/28/1999
Pages: 207
Product dimensions: 6.70(w) x 9.50(h) x 0.50(d)

About the Author

Jerome A. Berson received a B.S. in chemistry from the City Collegeof New York in 1944. After a brief period in the industry withHoffmann-La Roche in New Jersey, he served in the Army of theUnited Stated (1944-1946, China-Burma-India Theater). In 1946, heentered graduate study at Columbia University where he took M.A.and Ph.D. degrees with W. von E. Doering. He was a post-doctoralfellow at Harvard University (with R. B. Woodward) in 1949-1950.Subsequently, he taught chemistry at the University of SouthernCalifornia (1950-1963), the University of Wisconsin (1963-1969),and Yale University (since 1969). He is presently SterlingProfessor Emeritus of Chemistry at Yale.
His research group has concentrated its efforts on the elucidationof reaction mechanisms and the synthesis of molecules oftheoretical interest. In the latter category, a principal activityhas been the study of non-Kekulé compounds.
In recent years, he has written on the history of science,producing a number of articles and two books, both published byWiley-VCH: Chemical Discovery and the Logicians' Program (2003) andthe present book, Chemical Creativity.

Table of Contents

INTRODUCTION
The Nature of Science and the History of Science
An Experiment
DISCOVERIES MISSED, DISCOVERIES MADE -
TWO CASE STUDIES OF CREATIVITY IN CHEMISTRY
Science and the Individual
Diels, Alder, Their Competitors, and the Discovery of the DieneSynthesis
Thiele
The Alternation Effect and the Discovery of Orbital Symmetry
ERICH HÜCKEL AND THE THEORY OF AROMATICITY -
REFLECTIONS ON THEORY AND EXPERIMENT
Debye-Hückel Theory of Electrolytic Solutions
Nature of the Double Bond
Hybridization in Double Bonds
Benzene Problem
MO Description of Conjugated Cyclic Compounds
Orbital Symmetry (Woodward-Hoffmann Rules)
Extension of Cyclic p-Electron MO Theory to Transition States ofPericyclic Reactions
Violation of Hund's Rule in Biradicals
Reflections on Hückel's Career
THE DIENONE-PHENOL MYSTERIES
Isolations of Estrogens
Approaches to the Estrogens by Aromatization of Ring A
Alicyclic Steroids
Woodward's Challenge
Misgivings about the Structures
Why did Woodward Undertake the Correction of the PhenolicStructures?
Woodward and the Total Synthesis of Steroids
Approaches and Achievements
Mechanistic Motivation
MEDITATIONS ON THE SPECIAL CONVICTIVE POWER OF SYMMETRIZATIONEXPERIMENTS
Enolization as a Mechanism of Symmetrization
The Menthone Problem
Tricyclene and the Wagner-Meerwein Rearrangement
The Pinacol Controversy
The Favorskii Rearrangement
Symmetrization
Racemization Machines with no Achiral Parts
Direct Nucleophilic Displacement Reaction
The Walden Inversion
Biological and Evolutionary Attraction of Symmetry
Epilogue

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