Chemical Creativity: Ideas from the Work of Woodward, Huckel, Meerwein, and Others / Edition 1 available in Paperback
- Pub. Date:
Where are the origins of chemical ideas? How did the pioneers inchemistry recognize the fundamental intellectual issues of theirtime? What skills of reasoning and experiment did they use to solvethese problemes? How did the circumstances of personality andcompetition influence their careers and scientific accomplishments?If we can answer these questions, we may be able to improve our ownchances of success in research.»This is a marvelous book of people and chemical ideas! Theauthor, Jerry Berson, is known as a chemical stylist, a physicalorganic chemist possessed of the highest analytical powers. In aunique approach to the history of chemistry (indeed the history ofscience) he brings that style, as well as his insider's knowledgeand a perceptive sensivity to the societal setting of chemists, tothe analysis of some key chapters in modern organicchemistry.« Roald Hoffmann, Nobel Laureate
|Product dimensions:||6.70(w) x 9.50(h) x 0.50(d)|
About the Author
Jerome A. Berson received a B.S. in chemistry from the City Collegeof New York in 1944. After a brief period in the industry withHoffmann-La Roche in New Jersey, he served in the Army of theUnited Stated (1944-1946, China-Burma-India Theater). In 1946, heentered graduate study at Columbia University where he took M.A.and Ph.D. degrees with W. von E. Doering. He was a post-doctoralfellow at Harvard University (with R. B. Woodward) in 1949-1950.Subsequently, he taught chemistry at the University of SouthernCalifornia (1950-1963), the University of Wisconsin (1963-1969),and Yale University (since 1969). He is presently SterlingProfessor Emeritus of Chemistry at Yale. His research group has concentrated its efforts on the elucidationof reaction mechanisms and the synthesis of molecules oftheoretical interest. In the latter category, a principal activityhas been the study of non-Kekulé compounds.In recent years, he has written on the history of science,producing a number of articles and two books, both published byWiley-VCH: Chemical Discovery and the Logicians' Program (2003) andthe present book, Chemical Creativity.
Table of ContentsINTRODUCTIONThe Nature of Science and the History of ScienceAn ExperimentDISCOVERIES MISSED, DISCOVERIES MADE -TWO CASE STUDIES OF CREATIVITY IN CHEMISTRYScience and the IndividualDiels, Alder, Their Competitors, and the Discovery of the DieneSynthesisThieleThe Alternation Effect and the Discovery of Orbital SymmetryERICH HÜCKEL AND THE THEORY OF AROMATICITY -REFLECTIONS ON THEORY AND EXPERIMENTDebye-Hückel Theory of Electrolytic SolutionsNature of the Double BondHybridization in Double BondsBenzene ProblemMO Description of Conjugated Cyclic CompoundsOrbital Symmetry (Woodward-Hoffmann Rules)Extension of Cyclic p-Electron MO Theory to Transition States ofPericyclic ReactionsViolation of Hund's Rule in BiradicalsReflections on Hückel's CareerTHE DIENONE-PHENOL MYSTERIESIsolations of EstrogensApproaches to the Estrogens by Aromatization of Ring AAlicyclic SteroidsWoodward's ChallengeMisgivings about the StructuresWhy did Woodward Undertake the Correction of the PhenolicStructures?Woodward and the Total Synthesis of SteroidsApproaches and AchievementsMechanistic MotivationMEDITATIONS ON THE SPECIAL CONVICTIVE POWER OF SYMMETRIZATIONEXPERIMENTSEnolization as a Mechanism of SymmetrizationThe Menthone ProblemTricyclene and the Wagner-Meerwein RearrangementThe Pinacol ControversyThe Favorskii RearrangementSymmetrizationRacemization Machines with no Achiral PartsDirect Nucleophilic Displacement ReactionThe Walden InversionBiological and Evolutionary Attraction of SymmetryEpilogue