Reports from the fifth workshop for investigators carrying out prospective longitudinal studies on children and young adults with sex chromosome anomalies are presented. Part I updates the studies and provides an unbiased summary of the prognosis for a fetus or newborn diagnosed with a sex chromosome anomaly. Part II deals with clinical and therapeutic observations and provides the first critical attempt at evaluating various therapeutic modes which may be useful for patients with the 45,X and 47,XXY karyotypes. There is also critical information concerning patients with Turner and Klinefelter syndromes. The book, the result of more than 20 years of international effort, will be of value to professionals who treat patients with sex chromosome anomalies and their families as well as to those who assist couples in making informed choices about pregnancy.
Table of Contents
Partial table of contents:
FOLLOW UP OF CHILDREN AND YOUNG ADULTS WITH SEX CHROMOSOME ANEUPLOIDY.
Edinburgh Study of Growth and Development of Chidren with Sex Chromosome Abnormalities IV (S. Ratcliffe, et al.).
Sex Chromosome Aneuploidy: The Denver Prospective Study (A. Robinson, et al.).
Growth, Development and Behavior Outcome from Mid-Adolescence to Adulthood of Subjects with Chromosome Aneuploidy: The Toronto Study (D. Stewart, et al.).
Follow-up of 25 Unselected Children with Sex Chromosome Abnormalities Till the Age of 10-14 Years (J. Nielsen).
Summary of Clinical Findings in Children and Young Adults with Sex Chromosome Anomalies (A. Robinson, et al.).
CLINICAL AND THERAPEUTIC OBSERVATIONS OF PATIENTS WITH SEX CHROMOSOME ANEUPLOIDY.
Growth Hormone Therapy in Girls with Turner Syndrome (H. Dean).
Sex Chromosomal and Autosomal Aneuploidy in the Fragile X Syndrome (A. Chudley).
Sex Chromosome Anomalies: Prenatal Diagnosis and the Need for Continued Prospective Studies (J. Evans, et al.).
MOLECULAR STUDIES ON THE ORIGIN OF NON-DISJUNCTION IN CHILDREN WITH SEX CHROMOSOME ANOMALIES.
The Human X Chromosome (J. Hamerton).
The Parental Origin of 47,XXY Males (J. Harvey, et al.).
The Parental Origin of the Missing or Additional Chromosome in 45,X and 47,XXX Females (T. Hassold, et al.).