Chromosome Translocation

Chromosome Translocation

by Yu Zhang (Editor)

Hardcover(1st ed. 2018)

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This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases.

The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation.

It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.

Product Details

ISBN-13: 9789811305924
Publisher: Springer Singapore
Publication date: 06/29/2018
Series: Advances in Experimental Medicine and Biology , #1044
Edition description: 1st ed. 2018
Pages: 168
Product dimensions: 7.01(w) x 10.00(h) x (d)

About the Author

Dr. Yu Zhang is Assistant Investigator at National Institute of Biological Sciences, Beijing, China.

Table of Contents

Chapter 1: Historical and clinical overview of chromosome translocations.- Chapter 2: Next generation sequencing to identify chromosome translocation.- Chapter 3: The experimental models to study chromosome translocations.- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome.- Chapter 5: Live cell imaging to study chromosome translocation.- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo.- Chapter 7: Generation of DNA double strand breaks (DSBs).- Chapter 8: The role of DSB response pathway in regulating chromosome translocation.- Chapter 9: DSB repair and ligation of chromosome translocation.- Chapter 10: 3D genome organization defines the chromosome translocation pattern.- Chapter 11: Mechanisms of chromosome deletion.- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection.

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