This comprehensive reference covers the impact of dietary phosphorus in phosphorus physiology, public health and the pathogenesis of disease. Divided into three parts, the first section is an overview of the history of phosphorus and the regulation of phosphorus homeostasis. The second section focuses on specific matters related to phosphorus in the food supply. Clinical applications of the material presented in the preceding sections are pulled together in the third section - including the importance of both phosphorus excess and phosphorus deficiency for the pathogenesis of a wide variety of disease including kidney, cardiovascular, bone and oncologic diseases.
Clinical Aspects of Natural and Added Phosphorus in Foods is an indispensable resource for understanding the growing importance of dietary phosphorus content in health and disease, enhancing patient care and moving forward the field of phosphorus science.
About the Author
Orlando M. Gutiérrez, MD, MMSc
Division of Nephrology, Department of Medicine, School of Medicine
Department of Epidemiology, School of Public Health
University of Alabama at Birmingham
Kamyar Kalantar-Zadeh, MD, MPH, PHD, FAAP, FACP, FASN, FAHA, FNKF
Chief, Division of Nephrology & Hypertension
Professor of Medicine, Pediatrics and Public Health
University of California Irvine, School of Medicine, Orange and Irvine, CA
Adjunct Professor of Epidemiology
Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA
Staff Physician and Principal Investigator
Veterans Affairs (VA) Long Beach Healthcare System, Long Beach, CA
Rajnish Mehrotra MD, MS
Professor of Medicine
Section Head, Division of Nephrology
Harborview Medical Center
University of Washington
Table of Contents
I. Basic Phosphorus Physiology.- 1. The Story of Phosphorus.- 2. Overview of Phosphorus Homeostasis.- 3. Hormonal Regulation of Phosphorus Homeostasis: Parathyroid Hormone, Fibroblast Growth Factor 23, and Klotho.- II. Phosphorus in food.- 4. Phosphorus in the Modern Food Supply: Underestimation of Exposure.- 5. Nutritional Aspects of Phosphorus Compounds in Foods.- 6. Phosphorus Additives in Food Processing.- 7. Effects of Natural and Added Phosphorus Compounds in Foods in Health and Disease.- 8. Phosphorus Utilization in Animal Agriculture.- 9. Technical Aspects about Measuring Phosphorus in Food.- III. Phosphorous – Nutrient interactions.- 10. Interaction Between Calcium and Phosphorus and the Relationship to Bone Health.- 11. Phosphate Deficiency and the Phosphate Depletion Syndrome: Pathophysiology, Diagnosis, and Treatment.- 12. Dietary Phytate and Interactions with Mineral Nutrients.- IV. Phosphorus and Disease.- 13. Phosphorus and Kidney Disease: Mechanisms for Perturbed Phosphorus Homeostasis in Chronic Kidney Disease.- 14. Hidden Forms of Phosphorus in the Diet: Impact in the General Population and in Individuals with Chronic Kidney Disease.- 15. Dietary Phosphorus and Bone Disease.- 16. Phosphorus and Cardiovascular Disease.- 17. Phosphorus and Malignancies.