Pub. Date:
Elsevier Health Sciences


Current price is , Original price is $240.0. You

Temporarily Out of Stock Online

Please check back later for updated availability.

This item is available online through Marketplace sellers.


A must-have reference, this new edition provides practical information on treatment guidelines, details of diagnosis and therapy, and personal recommendations on patient management from experts in the field. Consistently formatted chapters allow for a user-friendly presentation for quick access of key information by the practicing clinician. Completely updated, this new edition includes all of the latest developments in treatment strategies of medical, surgical and radiation oncologists.

Product Details

ISBN-13: 9780443075452
Publisher: Elsevier Health Sciences
Publication date: 12/24/1999
Edition description: Older Edition
Pages: 2963
Product dimensions: 8.75(w) x 11.25(h) x (d)

Table of Contents

Part IScience of Clinical Oncology1
Section 1Biology and Cancer
1.Molecular Tools in Cancer Research3
2.Intracellular Signaling19
3.The Cellular Microenvironment47
4.Biology of Cancer Metastasis59
5.Control of the Cell Cycle81
6.Cell Life and Cell Death101
7.Immunology and Cancer113
8.Stem Cells, Cell Differentiation, and Cancer139
9.Vascular and Interstitial Biology of Tumors153
Section 2The Genesis of Cancer
10.Environmental Factors173
11.DNA Damage Response Pathways and Cancer191
12.Viruses and Human Cancer207
13.Genetic Factors: Hereditary Cancer Predisposition Syndromes227
14.Genetic Factors: Finding Cancer Susceptibility Genes253
15.Progressing from Gene Mutations to Cancer269
16.Immunodeficiency and Cancer287
Section 3Diagnosing Cancer
17.Pathology and Laboratory Medicine299
Surgical Pathology300
Flow Cytometry in Oncologic Diagnosis305
Molecular Diagnostics320
Clinical Chemistry: Tumor Markers329
Section 4Preventing and Treating Cancer
19.Biostatistics for Clinical Trials365
20.Structures Supporting Cancer Clinical Trials383
21.Economic Analysis of Cancer Treatment395
22.Epidemiology and Population Sciences407
23.Cancer Prevention, Screening, and Early Detection425
24.Smoking Cessation: Current Treatments and Future Directions473
26.The Basics of Radiation Therapy537
27.Surgical Interventions in Cancer579
28.Bone Marrow Transplantation591
29.Gene Therapy in Oncology603
30.The Present and Future of Molecularly Targeted Therapy623
31.Photodynamic Therapy639
32.Therapeutic Antibodies and Immunologic Conjugates661
33.Cancer Vaccines677
34.Complementary and Alternative Medicine695
Part IIProblems Common to Cancer and Its Therapy713
Section 1Symptom Management and Palliative Care
35.Cancer Pain715
36.Rehabilitation of the Patient with Cancer731
38.Nausea and Vomiting759
39.Oral Complications775
40.Alopecia and Cutaneous Complications793
43.Caring for Patients at the End of Life847
Section 2Hematologic Problems
44.Disorders of Blood Cell Production in Clinical Oncology861
45.Diagnosis, Treatment, and Prevention of Cancer-Related Venous Thrombosis891
Section 3Infections
46.Fever in the Neutropenic Cancer Patient925
47.Infection in the Severely Immunocompromised Patient941
Section 4Metabolic and Paraneoplastic Syndromes
50.Tumor Lysis Syndrome987
51.Paraneoplastic Neurologic Syndromes993
Section 5Surgical Problems
52.Establishing and Maintaining Vascular Access1007
53.Acute Abdomen, Bowel Obstruction, and Fistula1025
Section 6Local Effects of Cancer and Its Metastasis
54.Superior Vena Cava Syndrome1047
55.Spinal Cord Compression1063
56.Brain Metastases and Carcinomatous Meningitis1073
57.Bone Metastases1091
58.Lung Metastases1129
59.Liver Metastases1141
61.Neurologic Complications1213
62.Pulmonary Complications of Anticancer Treatment1237
63.Cardiac Effects of Cancer Therapy1251
64.Reproductive Complications1269
65.Endocrine Complications1287
66.Second Malignant Neoplasms1297
Section 7Special Issues
67.Cancer in the Elderly: Biology, Prevention, and Treatment1317
68.Special Issues in Pregnancy1331
Part IIISpecific Malignancies1345
69.Cancer of the Central Nervous System1347
70.Eye, Orbit, and Adnexal Structures1433
71.Cancer of the Head and Neck1497
73.Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas1589
74.Cancer of the Endocrine System1611
75.Cancer of the Lung: NSCLC and SCLC1649
76.Tumors of the Pleura and Mediastinum1745
77.Cancer of the Esophagus1787
78.Cancer of the Stomach1819
79.Cancer of the Small Bowel1863
80.Colon Cancer1877
81.Cancer of the Rectum1943
82.Cancer of the Anal Canal1967
83.Liver and Bile Duct Cancer1981
84.Carcinoma of the Pancreas2015
85.Kidney and Ureter2035
86.Carcinoma of the Bladder2059
87.Prostate Cancer2085
88.Cancer of the Penis and Urethra2149
89.Testicular Cancer2175
90.Cancers of the Cervix, Vagina, and Vulva2217
91.Cancer of the Uterus2273
92.Ovaries and Fallopian Tubes2311
93.Gestational Trophoblastic Disease2347
94.Cancer of the Breast2369
95.Sarcomas of Bone2471
96.Sarcomas of Soft Tissue2573
97.Unknown Primary Cancer2627
98.HIV-Associated Malignancies2647
99.Pediatric Solid Tumors2661
100.The World Health Organization Classification of Hematologic Malignancies2723
101.Childhood Leukemia2731
102.Childhood Lymphoma2765
103.Acute Lymphoid Leukemia in Adults2793
104.Acute Myeloid Leukemia in Adults2825
105.The Myelodysplastic Syndromes2849
106.Chronic Myeolo-proliferative Diseases2883
107.Chronic Myeloid Leukemia2899
108.Chronic Lymphoid Leukemias2921
109.Hairy Cell Leukemia2941
110.Multiple Myeloma and Related Disorders2955
111.Hodgkin's Lymphoma2985
112.Non-Hodgkin's Lymphoma3015
113.Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma3077
114.Adult T-Cell Leukemia-Lymphoma3109

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews