Colorectal Cancer / Edition 1

Colorectal Cancer / Edition 1

by Maurizio Ponz de Leon
ISBN-10:
3642627625
ISBN-13:
9783642627620
Pub. Date:
08/17/2012
Publisher:
Springer Berlin Heidelberg
ISBN-10:
3642627625
ISBN-13:
9783642627620
Pub. Date:
08/17/2012
Publisher:
Springer Berlin Heidelberg
Colorectal Cancer / Edition 1

Colorectal Cancer / Edition 1

by Maurizio Ponz de Leon

Paperback

$109.99 Current price is , Original price is $109.99. You
$109.99 
  • SHIP THIS ITEM
    Qualifies for Free Shipping
  • PICK UP IN STORE
    Check Availability at Nearby Stores

Overview

Colorectal cancer is one of the most frequent human tumors. Despite tremendous advances in our knowledge about the pathogenesis of the disease, the prognosis remains poor for almost half of the individuals affected. This volume provides an updated and comprehensive description of the most relevant features of colorectal cancer - from molecular biology to prevention, from hereditary syndromes to new treatment modalities. It represents an invaluable source for clinicians who deal with colorectal neoplasms and for all those who wish to increase their knowledge of these malignancies.

Product Details

ISBN-13: 9783642627620
Publisher: Springer Berlin Heidelberg
Publication date: 08/17/2012
Edition description: Softcover reprint of the original 1st ed. 2002
Pages: 303
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1 The Causes of Colorectal Cancer.- Descriptive Epidemiology and Temporal Trends.- The Environment and Colorectal Cancer.- Diet and Micronutrients.- Physical Activity, Obesity and Energy Imbalance.- Hormonal Factors.- Smoking and Alcoholic Beverages.- Inflammatory Bowel Diseases.- Drugs.- Colorectal Polyps and the Adenoma-Carcinoma Sequence.- Familial and Hereditary Factors.- Familial Colorectal Cancer.- Hereditary Non-polyposis Colorectal Cancer.- Familial Adenomatous Polyposis.- Gene-Environment Interactions.- Conclusions.- References.- 2 Pathogenesis of Colorectal Cancer.- Main Causes of Colorectal Cancer.- Pathogenesis of Colorectal Cancer: Different Molecular Pathways for One Disease.- Sporadic Colorectal Cancer Development (Loss of Heterozygosity Pathway).- Tumor Development in FAP and Other Polyposis Syndromes.- Colorectal Tumorigenesis in HNPCC (Mutator Genes/Microsatellite Instability Pathway).- The Mitotic Checkpoint Gene Mutation Pathway.- Colorectal Cancer Development in Inflammatory Bowel Diseases.- Tumor Development Through the I1307 K Mutation of the APC Gene: Some Clues to Familial Cancer.- Conclusions.- References.- 3 Pathology of Colorectal Cancer.- The Colorectal Mucosa.- Normal Architecture.- Cell Proliferation.- Aberrant Crypts.- Adenomatous Polyps.- Descriptive Epidemiology.- Distribution, Size and Multiplicity.- Histopathology, Dysplasia and “Malignant Polyps”.- Adenomas in Familial Adenomatous Polyposis and Hereditary Non-polyposis Colorectal Cancer.- The Adenoma-Carcinoma Sequence.- Etiology of Adenomatous Polyps.- Other Types of Polyps.- Hyperplastic, Mixed Polyps and Serrated Adenomas.- Flat Adenomas.- Hamartomatous Polyps.- Polyps and Dysplasia in Inflammatory Bowel Diseases.- Other Benign Tumors.- Colorectal Carcinoma.- Adenoma-Carcinoma Sequence Versus “De Novo” Carcinogenesis.- Macroscopic Appearance.- Histological Features and Grading.- Pattern of Metastasis and Staging.- Other Tumors of the Large Bowel.- Conclusions.- References.- 4 Diagnosis and Clinical Features of Colorectal Cancer.- Clinical Findings: Symptoms and Signs.- Laboratory Investigations.- Diagnosis of Colorectal Cancer: Old Methods and Recent Imaging Techniques.- Imaging Studies in Primary Cancer.- Imaging Studies in the Diagnosis of Recurrent or Metastatic Disease.- Conclusions.- References.- 5 Colorectal Cancer Screening and Surveillance.- Colorectal Cancer Screening in the General Population.- Role of Fecal Occult Blood Testing.- Role of Sigmoidoscopy.- Role of Colonoscopy and Barium Enema.- New Screening Procedures Based on Molecular Analysis.- Screening in Individuals with Familial Colorectal Cancer.- Understanding the Nature of the Familial Risk.- Screening Recommendations for Individuals with Familial Risk.- Surveillance After Endoscopic Polypectomy.- Surveillance After Surgery for Colorectal Cancer.- Surveillance in Patients with Inflammatory Bowel Disease.- Surveillance in Hereditary Cancer Syndromes.- Familial Adenomatous Polyposis.- Hereditary Non-polyposis Colorectal Cancer.- Conclusion: Media, Society and Colorectal Cancer Screening.- References.- 6 Prevention and Chemoprevention of Colorectal Neoplasms.- Can We Prevent Colorectal Cancer with an Appropriate Diet?.- Can We Prevent Colorectal Cancer by Modifying Our Lifestyle?.- Secondary Prevention: Is the Removal of Adenomas Effective?.- Colorectal Cancer Prevention Under Special Conditions.- Chemoprevention of Colorectal Cancer.- General Concepts of Chemoprevention.- Main Compounds Used in the Chemoprevention of Colorectal Tumors.- Conclusions.- References.- 7 Treatment of Colorectal Cancer.- Staging Colorectal Neoplasms.- Treatment of Resectable Colorectal Tumors.- Endoscopic Treatment of Malignant Polyps.- Surgical Treatment of Resectable Tumors of the Colon.- Surgical Treatment of Resectable Tumors of the Rectum.- Medical Treatment of Colorectal Tumors.- Radiation Treatment of Rectal Cancer.- Management of Locally Recurrent Cancer.- Treatment of Advanced Colorectal Tumors.- Surgical Treatment of Metastatic Colorectal Cancer.- Chemotherapy for Advanced Colorectal Cancer.- Toxicity and Cost of Chemotherapy in Advanced Colorectal Cancer.- Other Treatments for Advanced Colorectal Neoplasms.- Innovative Treatments for Colorectal Cancer.- Conclusions.- References.- 8 Survival and Follow-up of Colorectal Cancer.- Factors Influencing Colorectal Cancer Survival.- Gender, Age and Stage at Diagnosis.- Morphological and Clinical Indicators.- Cell Replication, Nuclear Ploidy and Colorectal Cancer Survival.- Molecular Markers of Prognosis.- Micrometastases and Prognosis.- Temporal Trends and Ethnic Differences in Colorectal Cancer Survival.- Follow-up of Colorectal Cancer Patients.- Proposed Surveillance Programs After Colorectal Cancer Resection.- Controlled Studies Evaluating the Effectiveness of Follow-up.- Conclusions.- References.- 9 Cancer of the Anal Canal.- Epidemiology of Anal Cancer.- Descriptive Epidemiology.- Risk Factors.- Clinical Features and Pathology.- Treatment of Cancer of the Anus.- Radiotherapy Alone.- Combination Therapy.- Conclusions.- References.- 10 Hereditary Non-polyposis Colorectal Cancer (Lynch Syndrome).- Brief History of HNPCC.- Epidemiology and Frequency of Lynch Syndrome.- Formal Genetics and the Role of Family History.- Clinical Features of HNPCC.- Age at Diagnosis and Preferential Location in the Right Colon.- Multiple Tumors.- Tumor Spectrum.- Pathology of HNPCC.- Molecular Biology of HNPCC.- DNA Mismatch Repair in Bacteria.- Human Mismatch Repair Genes in Lynch Syndrome.- Microsatellite Instability: the MSI+ Phenotype.- Microsatellite Instability and Cancer Development.- Frequency of Mutations in HNPCC Families.- New Genes Predisposing to HNPCC.- Diagnosis of HNPCC.- Identification of HNPCC.- Suspected HNPCC.- Genetic Counseling in HNPCC.- Management and Survival.- Treatment and Follow-up.- Survival.- Conclusions.- References.- 11 Familial Adenomatous Polyposis.- Definition and Historical Overview.- Epidemiology and Formal Genetics.- Diagnosis, Clinical Features and Morphology.- Colorectal Lesions.- Extracolonic Manifestations.- Molecular Biology of FAP.- The APC Gene and Its Functions.- Genotype-Phenotype Correlations.- Methods for Study of the APC Gene.- Management of Familial Adenomatous Polyposis.- The Role of Counseling in the Diagnosis and Surveillance of Adenomatosis Coli.- Surgical Treatment of FAP.- Overall Prognosis and Follow-up.- Medical Treatment.- Conclusions.- References.- 12 Other Polyposis of the Large Bowel.- Peutz-Jeghers Syndrome.- Clinical Manifestations and Morphology.- Molecular Biology of PJS.- Management.- Juvenile Polyposis.- Phenotypic Characteristics, Genetics and Cancer Risk.- Molecular Biology and Genetic Heterogeneity of JP.- Management of JP.- Cowden’s Disease.- Clinical Manifestations and Morphology.- Molecular Basis of CD.- Management of CD.- Turcot Syndrome.- Clinical and Morphologic Aspects of TS.- Complex Genetic and Molecular Basis of TS.- Management of TS.- Muir-Torre Syndrome and Other Rare Polyposis.- Clinical and Morphologic Features of MTS.- Molecular Biology of MTS.- Management of MTS.- Cronkhite-Canada Syndrome.- Bannayan-Riley-Ruvalcaba Syndrome.- Conclusions.- References.- 13 Carcinoid Tumors of the Large Bowel.- Brief History.- Biology and Pathology of CT.- Clinical Features of Colorectal CT.- Diagnosis and Treatment of CT of the Large Bowel.- Diagnosis of CT.- Treatment of the Primary Tumor.- Treatment of Metastatic CT.- Conclusions.- References.- 14 Colorectal Cancer at the Beginning of the New Millennium.- The Colorectal Cancer Epidemic.- Gene-Environment Interaction.- Dealing with Colorectal Cancer Patients in the “Molecular Era”.- References.
From the B&N Reads Blog

Customer Reviews