Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides

Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides

by Elsevier Science

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Product Details

ISBN-13: 9780080923352
Publisher: Elsevier Science
Publication date: 04/10/2009
Series: Methods in Enzymology , #458
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 350
File size: 21 MB
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Table of Contents

Part 1: Overview articles

Introduction - chemical classes of complex natural products and overview of their biosynthesis
Discovery of novel natural products
Trans-modification of intermediates on the assembly line in PKS, FAS and NRPS biosynthesis
Post-assembly line modifications, including glycosylation
Cloning and analysis of natural product pathways
In silico prediction of pathways from DNA sequence
Mass spectrometric analysis of PKS and NRPS biosynthetic intermediates
Synthetic probes for PKS and NRPS biochemistry
Directed evolution of natural products
Expression in a heterologous host
Pathway-specific and global regulation of antibiotic biosynthesis:
Regulation of antibiotic production by bacterial hormones:

Part 2: Peptides

A. Non-ribosomally-synthesised peptides

Overview of NRPSs, and mechanistic and structural studies
Siderophores
Cephamycins and clavulanic acid
Glycopeptides
Lipopeptides
Precursor Biosynthesis

B. Ribosomally synthesised peptides

Lantibiotic biosynthesis and engineering of novel compounds
Cyclic peptides from marine bacteria

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