Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture Models

Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture Models

by Bruno Sarmento

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Product Details

ISBN-13: 9780081000946
Publisher: Elsevier Science
Publication date: 10/23/2015
Pages: 408
Product dimensions: 6.00(w) x 9.10(h) x 1.00(d)

About the Author

Bruno Sarmento is an Affiliated Investigator at the INEB-Instituto de Engenharia Biomédica, based at the University of Porto, Portugal and is Assistant Professor of Pharmaceutical Technology in the Department of Pharmaceutical Sciences, at ISCS-N, Gandra, Portugal. His current research is focused on the study of nanomedicines and their application in the pharmaceutical and biomedical fields, as well as the use of in vitro cell models as a tool to correlate the transport of biopharmaceuticals and nanoparticles across human mucosa. Bruno has been involved with more than two hundred publications, including three edited books in the field of Pharmaceutical Technology and Nanomedicine, more than one hundred papers in international peer-review journals and several conference proceedings. He also serves as an editorial board member for several international journals and an evaluator of research projects form international agencies. He is an active member of several international associations (AAPS, CRS, EUFEPS, EFSD, FIP) and works on biotechnology and health post-graduate programs at national and international level.

Table of Contents

1. Introduction

2. Importance and applications of cell and tissue-based in vitro models for drug permeability screening in early stages of drug development

3. Immortalized cell-based in vitro culture models for drug permeability studies

4. Primary isolated cell-based in vitro culture models for drug permeability studies

5. Tissue-based in vitro culture models for drug permeability studies

6. Correlation between cell and tissue-based in vitro models for drug permeability screening with in vivo situation: Modeling and functional extrapolation

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