You wouldn't expect a detective with Sherlockian deductive skills to have amnesia, but Byron Constantine is hardly the detective you'd expect.
Aspiring artist Mira Blayse isn't concerned with upper-tier society or conforming to Victorian expectations-she has a murder to solve. At least, she thinks it was murder. Her parents' deaths in 1870 couldn't have been by accident, but the more she investigates, the less she seems to find. Sitting at a café, she sketches a mysterious stranger, not realizing that she's penciling in the features of the man who will help her solve the case once and for all.
Byron Constantine lives day-to-day, desperately trying to hold onto his memories, only for them to slip through his fingers. Some days, he doesn't even know that he's lost four years of his life. As he manages to continue his work as a private detective, he realizes that maybe he doesn't need his memory after all. That is until he wants to remember Mira Blayse.
With her keen eye for detail and his remarkable deductive skills, the two become entangled in a criminal investigation. As they uncover the secrets of the past, they must work together to stop history from repeating itself again.