Contemporary Topics in Immunobiology: Self/Non-self Discrimination

Contemporary Topics in Immunobiology: Self/Non-self Discrimination

by John J. Marchalonis (Editor)

Paperback(Softcover reprint of the original 1st ed. 1980)

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Product Details

ISBN-13: 9781461591337
Publisher: Springer US
Publication date: 12/27/2012
Series: Contemporary topics in immunobiology , #9
Edition description: Softcover reprint of the original 1st ed. 1980
Pages: 293
Product dimensions: 0.00(w) x 0.00(h) x 0.03(d)

Table of Contents

1 Discrimination of Self and Non-self in Plants.- I. Introduction.- II. Biology of Recognition Systems in Vascular Plants.- A. Some Case Histories of Somatic Interactions.- B. Some Case Histories of Sexual Interactions.- III. Immunobiology of Recognition Systems.- A. Antigenic Determinants of Somatic Cells and Protoplasts.- B. The Search for the S -Gene Product of Self-Incompatibility.- C. Recognition at the Pollen-Stigma Interface.- IV. Conclusions.- V. References.- 2 Discrimination of Self and Non-self in Invertebrates.- I. Introduction.- II. Non-self Recognition.- III. Serum Factors.- IV. Graft Studies and Invertebrate Histocompatibility Antigens.- V. References.- 3 Phylogeny of the Emergence of T-B Collaboration in Humoral Immunity.- I. Introduction: Primary and Secondary Lymphoid Sites.- II. Evidence of Lymphoid Heterogeneity: Differential Mitogenesis.- III. Evidence of Lymphoid Heterogeneity from Thymic Ablation.- IV. Evidence of Cell-Cell Collaboration in Ectotherms.- V. Conclusion: Some Speculations with Respect to the Evolution of Immunity.- VI. References.- 4 Lymphoid-Cell Cooperation in Immune Responses of the Chicken.- 5 Salamanders and the Evolution of the Major Histocompatibility Complex.- I. Introduction.- II. Does the MHC Exist in any Ectothermic Vertebrate?.- III. Do Salamanders Have the MHC?.- A. The Immunogenetic Basis of Allograft Rejection.- B. The Mixed Lymphocyte Reaction (MLR).- IV. Concluding Comments.- V. References.- 6 Membrane Immunoglobulins of Vertebrate Lymphocytes.- I. Introduction.- II. A Note on Methods for the Demonstration of Membrane Immunoglobulins.- III. Surface Immunoglobulins of Vertebrate Lymphocytes.- A. Universality of Lymphoid Heterogeneity in the Vertebrates.- B. B-Cell-Surface Ig.- C. T-Cell-Surface Ig.- D. Direct Demonstration of T-Cell Ig.- E. Molecular Properties of T-Cell Ig.- IV. Function of Lymphocyte-Surface Immunoglobulins.- V. Concluding Comments.- VI. References.- 7 Idiotypes, T-Cell Receptors, and T-B Cooperation.- I. Introduction.- II. Immunoglobulin Genes.- III. The Major Histocompatibility Complex.- A. The K/D Loci.- B. The/Region.- IV. Antigen Recognition by T Cells.- A. Recognition of Antigen by T Cells Is Very Precise.- B. Recognition of Antigen by T Cells Always Involves MHC Structures.- V. Subpopulations of T Cells.- A. Lyl Cells.- B. Ly23 Cells.- C. Ly123 Cells.- VI. The High Frequency of Alloreactive T Cells and Their Responsiveness to Nominal Antigen.- VII. T-Cell Receptors for Antigen Are Encoded in Conventional VH Genes.- A. T-Cell Receptors for Non-self MHC Antigens Carry Idiotypic Determinants.- B. T-Cell Receptors for Conventional, Non-MHC Antigens Carry Idiotypic Determinants.- VIII. Self/Non-self Discrimination by T Cells.- IX. The Association of Nominal Antigens with MHC Structures.- X. Cellular Interactions in Antibody Responses.- A. T-Cell-Macrophage Interaction in T-Cell Priming.- B. T-Cell-B-Cell Interaction in Antibody Responses.- C. Regulation of Immunoglobulin Quality by T Helper Cells.- D. Suppressor T Cells in Antibody Responses.- E. Feedback Loops in Immunoregulation.- F. Idiotypic Networks and Immunoregulation.- XI. Discussion.- XII. Summary.- XIII. References.- 8 An Immunologic Network.- I. Introduction.- II. The Immune System and Connectivity through Antigen.- III. Connectivity through Antigen and A Cells.- IV. Complementary Idiotypes.- V. A Minimal Network.- VI. Regulation.- VII. Is the Network Too Complex?.- VIII. The Network and Disease.- IX. Summary.- X. References.- 9 The Biological Function of the Major Histocompatibility Complex: Hypotheses.- I. Introduction.- II. Allograft Reaction.- III. Genetic Control of Immune Responses.- IV. Genetic Control of Complement Levels.- V. MHC Associations with Susceptibility and Resistance to Disease.- VI. Genetic Control of Traits Not Currently Classified as Immunological.- VII. Further Analyses of the Importance of MHC Antigens and Genes.- A. Frequency of H Mutations.- B. Adaptive Value of H-2 Polymorphism.- VIII. Conclusion.- IX. References.- 10 Molecular Interactions and Recognition Specificity of Surface Receptors.- I. Introduction.- II. Ground Rules.- III. Cell-Surface Molecules Implicated as Receptors.- IV. Structural Relationships among Surface Receptors.- V. Binding Parameters of Receptors.- VI. Combining Sites of Lectins and Antibodies.- VII. Primary Binding and Subsequent Early Membrane Events.- VIII. Conclusions: Primary Binding and Activation.- IX. References.

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