Crescent Lake National Wildlife Refuge is located in Garden County on the eastern edge of the Nebraska Panhandle. It lies on the southwestern edge of the 19,300 square mile Nebraska Sandhills, the largest sand dune area in the Western Hemisphere and one of the largest grass-stabilized regions in the world. The Sandhills are characterized by rolling, vegetated hills and interdunal valleys which are oriented in a northwest to southeast direction. Many shallow lakes and marshes are interspersed in the lower valleys. Native grasses predominate. Wildlife diversity, except large ungulates and their predators, is relatively unchanged since early settlement.