Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach

Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach

by Daniel C. Baumgart (Editor)

Paperback(Softcover reprint of the original 2nd ed. 2017)

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Product Details

ISBN-13: 9783319815770
Publisher: Springer International Publishing
Publication date: 06/18/2018
Edition description: Softcover reprint of the original 2nd ed. 2017
Pages: 695
Product dimensions: 8.27(w) x 10.98(h) x (d)

About the Author

Daniel C. Baumgart, MD

Inflammatory Bowel Disease Center

Department of Gastroenterology and Hepatology

Charité Medical Center--Virchow Hospital

Medical School of the Humboldt University of Berlin

Berlin,Germany

Table of Contents


Part 1 Epidemiology


Chapter 1 Environmental Factors in the Epidemiology of Inflammatory Bowel Disease
Morten H. Vatn


Part 2 Immunobiology


Chapter 2 The Intestinal Immune System in Health
Per Brandtzaeg


Chapter 3 Understanding the Epithelial Barrier in Inflammatory Bowel Disease
Matthew A. Odenwald, Jerrold R. Turner


Chapter 4 Intestinal Microbiology and Ecology in Crohn's Disease and Ulcerative Colitis
Dirk Haller, Ludovica F. Butto


Chapter 5 The Immune System in Inflammatory Bowel Disease: Antimicrobial Peptides
Charles L. Bevins


Chapter 6 Vascular Responses to Intestinal Inflammation
D. Neil Granger, Norman R. Harris


Chapter 7 Immunobiology of Human Dendritic Cells in Inflammatory Bowel Disease
Daniel C. Baumgart


Chapter 8 Immunobiology of T-Cells in Inflammatory Bowel Disease
S. Snapper, D. Nguyen, A Biswas


Chapter 9 Immunobiology of B cells in Inflammatory Bowel Disease
Atsushi Mizoguchi, Atul K. Bhan


Chapter 10 Immune Cells: Monocytes and Macrophages
Gerhard Rogler


Chapter 11 Immune Functions of Epithelial Cells in Inflammatory Bowel Disease
Eric L. Campbell, Sean P. Colgan


Chapter 12 Autophagy and Endoplasmic Reticulum Stress
Arthur Kaser


Chapter 13 Matrix Metalloproteinases
Paolo Biancheri, Thomas T. MacDonald


Chapter 14 Paradigm of T-cell Differentiation in Inflammatory Bowel Disease
Takashi Nagaishi, Mamoru Watanabe


Chapter 15 Pharmacological Intervention Studies Using Mouse Models of Chronic Intestinal Inflammation
Cynthia Reinoso Webb, Matthew B. Grisham


Chapter 16 Stem Cells and Organoids to Study Epithelial Cell Biology in Inflammatory Bowel Disease
Jorge O. Múnera, James M. Wells


Part 3 Diagnostic Approach


Chapter 17 Enhanced Endoscopy
Ralf Kiesslich


Chapter 18 Magnetic Resonance Enterography
Patrik Rogalla, Luis Guimaraes


Chapter 19 Computed Tomography Enterography and Inflammatory Bowel Disease
J. G. Fletcher


Chapter 20 Ultrasound in Inflammatory Bowel Disease
A. Potthoff, C. Agné, M. Gebel


Chapter 21 Laboratory Evaluation, Including Novel Diagnostic Markers
M. Flamant, X. Roblin


Chapter 22 Pathology of Inflammatory Bowel Disease
Nora E. Joseph, Christopher R. Weber


Chapter 23 Objective Assessment of Clinical Disease Activity
Edouard Louis, Catherine Van Kemseke, Catherine Reenaers


Chapter 24 Objective Assessment of Endoscopic Disease Activity and Mucosal Healing
Britt Christensen, David T. Rubin


Chapter 25 Evaluation of Quality of Life in Crohn's disease and Ulcerative Colitis: What Is Health-Related Quality of Life?
Katrine Carlsen, Pia Munkholm, Johan Burisch


Chapter 26 Evaluation of Health Economics in Inflammatory Bowel Disease
Reena Khanna, Brian G. Feagan


Part 4 Therapy Crohn’s Disease


Chapter 27 The Natural History of Inflammatory Bowel Disease
Charles N. Bernstein


Chapter 28 Conventional Medica Management of Crohn's Disease: Sulfasalazine
Miquel A. Gassull, Eduard Cabré


Chapter 29 Steroid Therapy for Crohn's Disease
A. Hillary Steinhart


Chapter 30 Thiopurines in Crohns' disease
Adi Lahat, Rami Eliakim


Chapter 31 Conventional Medical Management of Crohn's Disease: Methotrexate
Grace Harkin, Laurence Egan


Chapter 32 Adalimumab for the Treatment of Crohn’s Disease
Remo Panaccione


Chapter 33 Biologic Therapy of Crohn's Disease: Certolizumab
Alessandro Armuzzi, Daniela Pugliese


Chapter 34 Biologic Therapy of Crohn's Disease: Infliximab
Jan-Michael A. Klapproth, Gary R. Lichtenstein


Chapter 35 Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease Treatment
Peter J. Mannon

Chapter 36 Biologic Therapy of Crohn's Disease: Natalizumab, Vedolizumab and anti-MadCAM
Pieter Hindryckx, Geert D’Haens


Chapter 37 Optimal Management of Fistulizing Crohn's Disease
Bruce Sands, Farhad Peerani


Part 5 Therapy Ulcerative Colitis


Chapter 38 Sulfasalazine and 5-Aminosalicylates for Ulcerative Colitis
Reena Khanna, John K. Marshall


Chapter 39 Conventional Therapy of Ulcerative Colitis: Corticosteroids
Kirstin Taylor, Peter R. Gibson


Chapter 40 Medical Management of Ulcerative Colitis: Conventional Therapy--Azathioprine
Barrett G. Levesque, Edward V. Loftus


Chapter 41 Calcineurin Inhibitors in Ulcerative Colitis
Andreas Fischer, Daniel C. Baumgart


Chapter 42 Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab
Mindy Lam, Brian Bressler


Chapter 43 Biologic Therapy of Ulcerative Colitis: Adalimumab
Walter Reinisch


Chapter 44 Biologic Therapy of Ulcerative Colitis: Golimumab
Mark A. Samaan, Peter M. Irving


Chapter 45 Biologic Therapy of Ulcerative Colitis: Natalizumab, Vedolizumab, Etrolizumab (rHUMab beta 7), antiMadCAM
Severine Vermeire


Chapter 46 Probiotics, Prebiotics, and Antibiotics in Inflammatory Bowel Disease
Paolo Gionchetti, Carlo Calabrese, Andrea Calafiore, Fernando Rizzello


Chapter 47 Biosimiliars in the Treatment of Inflammatory Bowel Disease
Vivian W. Huang, Richard N. Fedorak


Chapter 48 Step-up vs. Top-down Approach in Crohn’s Disease
Christine Y. Yu, Daniel W. Hommes


Chapter 49 Leucocytapheresis Therapy of Inflammatory Bowel Disease
Takanori Kanai


Chapter 50 Surgical Management of Crohn's Disease and Ulcerative Colitis
Robert R. Cima, John H. Pemberton


Part 6 Extraintestinal Manifestations


Chapter 51 Extraintestinal Manifestations: Autoimmune Hepatitis
Michael Manns, Nora Schweitzer


Chapter 52 Primary Sclerosing Cholangitis
Roger W. Chapman, Kate D. Williamson


Chapter 53 Autoimmune Pancreatitis and Other Organ Involvement
Go Kuwata, Terumi Kamisawa


Chapter 54 Cutaneous and Oral Manifestations of Inflammatory Bowel Disease
Caroline P. Allen, Susan M. Burge


Chapter 55 Arthritis, Arthropathy and Osteoporosis in Inflammatory Bowel Disease
Alistair Tindell, Hanna Johnsson, Iain B. McInnes


Part 7 Nutrition


Chapter 56 Nutrition in Inflammatory Bowel Disease
Alan L. Buchman


Part 8 Pregnancy, Family Planning and Pediatric Aspects


Chapter 57 Pregnancy and Fertility in Inflammatory Bowel Disease
Rebecca Matro, Uma Mahadevan


Chapter 58 Pediatric Aspects of Inflammatory Bowel Disease
Brendan Boyle, Jeffrey S. Hyams


Part 9 Surveillance and Prevention


Chapter 59 Management and Prevention of Infectious Diseases in Irritable Bowel Disease Patients
Kristine Macartney, Nigel Crawford


Chapter 60 Incidence of Cancer and Screening in Inflammatory Bowel Disease
Jimmy K. Limdi, Francis A. Farraye


Chapter 61 Inflammatory Bowel Diseases: How to Identify High Risk Patients
Jacques Cosnes, Harry Sokol


Part 10 Patient Perspective and Resources


Chapter 62 Patient Perspective on Inflammatory Bowel Disease
Ayesha Williams, Marjorie Merrick


Chapter 63 Patient Resources in Inflammatory Bowel Disease
Sanna Lönnfors, Marco Greco

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